At least 30% of Americans are affected by chronic pain. Despite the inherent risks associated with opioid use and limited evidence for their usefulness for chronic pain treatment, opioids are still commonly prescribed. Opioids have been found to both initially relieve pain and then paradoxically increase pain sensitivity - a phenomenon known as opioid induced hyperalgesia (OIH). The purpose of this study was to highlight an effective pharmacological approach for opioid induced hyperalgesia in patients who are physiologically opioid dependent as a result of being prescribed opioids for their chronic pain. One case report of a patient experiencing chronic pain, opioid dependance, and OIH examined the effect of the medication buprenorphine extended-release injection (Sublocade) in addressing OIH. A Literature review about chronic pain and OIH treatments highlighted ketamine, methadone, dextromethorphan as being the commonly prescribed treatments. We present the results of one case in which a patient with chronic pain, opioid dependance and OIH was able to successfully taper off of opioids with resolution of her OIH. These findings offer a new approach to the treatment of OIH. Although a promising finding, more research and larger studies are needed to conclude the efficacy of Sublocade in the treatment of OIH in patients with chronic pain coinciding with and without opioid use disorder.