The crosstalk between cell death and pregnancy related diseases: A narrative review - 16/06/24
, Zhu Ru g, ⁎ , Yan Zhang c, a, ⁎ Abstract |
Programmed cell death is intricately linked to various physiological phenomena such as growth, development, and metabolism, as well as the proper function of the pancreatic β cell and the migration and invasion of trophoblast cells in the placenta during pregnancy. Traditional and recently identified programmed cell death include apoptosis, autophagy, pyroptosis, necroptosis, and ferroptosis. In addition to cancer and degenerative diseases, abnormal activation of cell death has also been implicated in pregnancy related diseases like preeclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, fetal growth restriction, and recurrent miscarriage. Excessive or insufficient cell death and pregnancy related diseases may be mutually determined, ultimately resulting in adverse pregnancy outcomes. In this review, we systematically describe the characteristics and mechanisms underlying several types of cell death and their roles in pregnancy related diseases. Moreover, we discuss potential therapeutic strategies that target cell death signaling pathways for pregnancy related diseases, hoping that more meaningful treatments will be applied in clinical practice in the future.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | The crosstalk between cell death and pregnancy related diseases is illustrated. |
• | The dysregulation of cell death closely correlates with pregnancy related diseases. |
• | Medications targeting cell death pathways hold promise for clinical application. |
Abbreviations : AIF, AIM2, AKT, AMP, AMPK, APAF-1, ASC, ASK1, ATF, ATG, ATP, BAK, BAX, BCL-2, BH3, BID, Bim, CFLIP, CHOP, CYLD, DAMPs, DISC, DMT1, DsDNA, Elf2α, Endo G, ER, ERK, ERp29, EVTs, FADD, FGR, FIP200, FOXO3, FTL, GCDCA, GDM, Glu, GLUT, GPX4, GSDMD/E, GSH, Hcy, HDACs , , HIF-1α, HTRA, ICP, IL-34, IRE1, IUGR , , JNK, LC3, LncRNAs, LPS, MLKL, MOMP, MTOR, MTORC1, NADPH, NF-κB, NINJ1, NLRC4, NLRP3, P38 MAPK, PAMPs, PI3K, Pe, PE, PERK, PLOOHs, PPARγ, PUFAs, RIPK, RM, ROS, RPL, RSA, RTK, SENG, SETD7, SIRT, SMAC, STAPA2, STAT1, STEAP3, TFR, TLR, TNFL, TNFR, TRADD, TRAF, TRAIL, TRIB3, TRIF, TSC1/2, TBID, ULK1, UPR, VEGF, VPS34, XIAP, ZBP1, ZIKV
Keywords : Cell death, Pregnancy related disease, Apoptosis, Autophagy, Pyroptosis, Necroptosis, Ferroptosis
Plan
Vol 176
Article 116815- juillet 2024 Retour au numéro
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