Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy - 01/08/24

Doi : 10.1016/j.clp.2024.04.008

Simone L. Huntingford, BComm/BSc, MBBS, FRACP ^a,^b,^c,^⁎ , Stephanie M. Boyd, BSc (Med), MPHTM, FRACP ^d,^e, Sarah J. McIntyre, PhD, MPS ^f,^{^{1
Present address: PO Box 171, Forestville, New South Wales 2087, Australia.}}, Shona C. Goldsmith, PhD ^f,^{^{1
Present address: PO Box 171, Forestville, New South Wales 2087, Australia.}}, Rod W. Hunt, PhD, FRACP, FRCP(UK) ^a,^b,^f, Nadia Badawi, AM ^d,^f
^a Department of Paediatrics, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
^b Monash Newborn, Monash Health, 246 Clayton Road, Clayton, Victoria 3168, Australia
^c Paediatric Infant Perinatal Emergency Retrieval, Royal Children’s Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia
^d Grace Centre for Newborn Intensive Care, The Children’s Hospital at Westmead, Hawkesbury Road, Westmead, New South Wales 2145, Australia
^e Faculty of Medicine and Health, University of Sydney, Campderdown, New South Wales 2006, Australia
^f CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia

^∗Corresponding author. Department of Paediatrics, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia.Department of PaediatricsMonash NewbornMonash University246 Clayton RoadClaytonVictoria3168Australia

Résumé

Hypoxic ischemic encephalopathy (HIE) is the most common cause of neonatal encephalopathy and results in significant morbidity and mortality. Long-term outcomes of the condition encompass impairments across all developmental domains. While therapeutic hypothermia (TH) has improved outcomes for term and late preterm infants with moderate to severe HIE, trials are ongoing to investigate the use of TH for infants with mild or preterm HIE. There is no evidence that adjuvant therapies in combination with TH improve long-term outcomes. Numerous trials of various adjuvant therapies are underway in the quest to further improve outcomes for infants with HIE.

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Keywords : Hypoxic ischemic encephalopathy (HIE), Neonatal, Neurodevelopmental (ND) outcome, Long-term, Cerebral palsy (CP), Cognition, Therapeutic hypothermia (TH)

Plan

Key points

Background

Outcomes

Moderate-to-Severe Hypoxic Ischemic Encephalopathy

Mild Hypoxic Ischemic Encephalopathy

Preterm Hypoxic Ischemic Encephalopathy

Evidence on Adjuvant Therapies

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Vol 51 - N° 3

P. 683-709 - septembre 2024 Retour au numéro

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Moving the Needle in Low-Resource Settings : Is Hypothermia a Friend or a Foe?
Reema Garegrat, Constance Burgod, Pallavi Muraleedharan, Sudhin Thayyil

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Communicating with Parents About Therapeutic Hypothermia and Hypoxic Ischemic Encephalopathy : Integrating a Palliative Care Approach into Practice
Alexa K. Craig, Sara Munoz-Blanco, Betsy Pilon, Monica Lemmon

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Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy - 01/08/24

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