Prediabetes and acute coronary syndrome: Characteristics and outcomes in a sub-Saharan Africa population - 16/01/25
, M.I.M. Kouamé 1, M. Affognitode 2, E. Ehouman 2, C. Touré 1, C. Gbassi 3, D. Koffi 4, R. N’Guetta 1Résumé |
Introduction |
Prediabetes (preDM) significantly increases the risk of major cardiovascular events. Data on preDM are limited in sub-Saharan Africa.
Objective |
To analyze in-hospital characteristics of patients with preDM admitted to the Abidjan Heart Institute for acute coronary syndrome (ACS).
Method |
We conducted a retrospective study based on data from the Registry of Acute Coronary Syndromes of Cote d’Ivoire (REACTIV) between 1 January 2021 and 31 December 2022. Clinical data, angiographic features and outcomes were analyzed and compared according to glycemic status based on HbA1c (glycated haemoglobin), separately in patients without a history of DM and in those with DM.
Results |
Of the 299 patients admitted for ACS, HbA1c was measured in 152 (50.83%). There was a male predominance (sex-ratio 3.75). The mean age was 58.8±10.7 years. Abnormal glucose regulation (previous DM, new DM and preDM) was identified in 71.71% of patients. Among patients without history of DM, compared with patients with normal glycaemia and patients with DM, there was a trend towards more severe coronary lesions, characterized by a higher rate of left main lesions (2.7%) and multivessel coronary artery disease (25%) in preDM patients. Recurrent myocardial infarction was more common in preDM patients compared to the other groups (p=0.04). There was a non-significant increase in the incidence of haemodynamic complications in preDM patients.
Conclusion |
Approximately 75% of patients admitted for ACS have impaired glucose metabolism. Pre-diabetes seems to be associated with a specific profile characterized by more severe coronary artery disease (CAD). However, these tendencies need to be confirmed by larger multicentre cohorts and assessment of the long-term prognosis of these patients.
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Vol 118 - N° 1S
P. S23 - janvier 2025 Retour au numéro
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