Novel PET-CT-MR Imaging Based Quantitative Technique for Accurate Assessment of Radiation Induced Injuries - 17/03/25

Doi : 10.1016/j.cpet.2025.01.008

Rithvik Kata, BS ^a,^b, Daniel Gharavi, BS ^c,^d, Shiv Patil, MS ^a,^b, Dev Patel, BS ^c,^e, Chitra Parikh, BA ^c,^e, Thomas Werner, MSE ^a, Charles B. Simone, MD ^f,^g,^{^{1
Co-senior authors.},}^⁎ , Abass Alavi, MD ^a,^{^{1
Co-senior authors.}}
^a Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
^b Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA
^c Department of Radiology, Hospital of the University of Pennsylvania, PA, USA
^d Virginia Commonwealth University, Richmond, VA, USA
^e Sidney Kimmel Medical College, Philadelphia, PA, USA
^f New York Proton Center, 225 East 126th Street, New York, NY 10035, USA
^g Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA

^∗Corresponding author. New York Proton Center, 225 East 126th Street, New York, NY 10035.New York Proton Center225 East 126th StreetNew YorkNY10035

Résumé

Radiation-induced injuries (RIIs) are significant complications of radiation therapy used in cancer treatments and affect organs in a systemic fashion such as the heart, lungs, liver, and bone marrow. Such ionizing radiation leads to inflammation, fibrosis, and/or irreparable DNA damage, each of which can significantly impact patient’s quality of life, underscoring the need for advanced diagnostic and imaging techniques. A novel combination of PET/Computed Tomography (CT) with Quantitative MR Imaging has emerged as a crucial tool for early diagnosis and timely evaluation of RIIs. This review focuses on the important role of quantitative PET-CT-MR imaging in diagnosing and monitoring RIIs.

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Keywords : Radiation induced injury, PET, MR imaging, Quantitative, Cardiopulmonary toxicity, Hepatotoxicity, Hematologic toxicity

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Key points

Introduction

Radiation-induced injuries

Mechanism of Injury

Normal Anatomy and Imaging Technique

Specific Toxicities

Quantitative PET metrics

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Vol 20 - N° 2

P. 253-264 - avril 2025 Retour au numéro

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Evolving Role of PET Imaging in Assessing Vascular and Central Nervous System Complications of Radiation Therapy in Head and Neck Cancer
Chitra Parikh, Justin Bridgers, Zhuorui Li, Alexander Gerlach, Dev Patel, Thomas Werner, Charles B. Simone, Abass Alavi

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Novel PET-CT-MR Imaging Based Quantitative Technique for Accurate Assessment of Radiation Induced Injuries - 17/03/25

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