The bidirectional interplay between gut dysbiosis and surgical complications: A systematic review - 26/05/25
Abstract |
Background |
The gut microbiome critically influences diverse aspects of physiology and surgical recovery. Conversely, surgery alters the microbiome, potentially predisposing to complications. We aimed to clarify the bidirectional interaction between surgery and gut dysbiosis.
Methods |
On December 22nd, 2024, a systematic search of the Cochrane Library, PubMed, VHL, and WOS was completed. Relevant studies were assessed for risk of bias using STROBE and CONSORT guidelines.
Results |
Thirty studies, with 2500+ participants experiencing diverse procedures and complications, were incorporated. Although specifics varied, dysbiosis correlated with surgery and its complications. Patients with complications had more harmful bacteria and fewer beneficial bacteria. In some studies, probiotics reduced complications.
Conclusion |
Gut dysbiosis is tied to postoperative complications in a complex, bidirectional relationship. Patients with surgical complications may have fewer beneficial and more pathogenic bacteria both before and after surgery. Early identification of dysbiosis and probiotic administration could predict or even reduce postoperative complications.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Created in BioRender. Nichols, L. (2025) dnzl1dw.
Highlights |
• | Postoperative outcomes affect and are affected by the gut microbiome. |
• | Worse outcomes are associated with more severe dysbiotic alterations. |
• | Probiotics improve some GI and extra-GI postoperative outcomes. |
• | This interplay can be utilized to predict and improve postoperative outcomes. |
• | Preoperative microbiome profiling can be used for risk stratification. |
Keywords : Gut dysbiosis, Gastrointestinal tract, Postoperative complications, Intraoperative complications, And patient outcome
Plan
Vol 245
Article 116369- juillet 2025 Retour au numéro
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