Aspergillus fumigatus lung abscess in two adolescents with cystic fibrosis - 09/07/25

Doi : 10.1016/j.mycmed.2025.101570

Maria Noni ^a,^⁎ , Anna Katelari ^b,^{^{1
Anna Katelari (former Consultant) and Stavros-Eleftherios Doudounakis (former Director) were members of the medical staff of the Department of Cystic Fibrosis when the work described in the article was done and are now retired.}}, Konstantinos Iosifidis ^c, Christina Kanaka-Gantenbein ^a, Aristea Velegraki ^d,^e, Georgia Papaioannou ^c, Stavros-Eleftherios Doudounakis ^b,^{^{1
Anna Katelari (former Consultant) and Stavros-Eleftherios Doudounakis (former Director) were members of the medical staff of the Department of Cystic Fibrosis when the work described in the article was done and are now retired.}}
^a First Department of Pediatrics, National and Kapodistrian University of Athens, Medical School, “Aghia Sophia” Children’s Hospital, Athens, Greece
^b Department of Cystic Fibrosis, “Aghia Sophia” Children’s Hospital, Athens, Greece
^c Department of Pediatric Radiology, Mitera Maternity and Children's Hospital, Athens, Greece
^d Mycology Laboratory, BIOIATRIKI S.A. Healthcare Group, 11526 Athens, Greece
^e Mycology Research Laboratory, Medical School, National and Kapodistrian University of Athens, Greece

^⁎Corresponding author at: First Department of Pediatrics, National and Kapodistrian University of Athens, Medical School, “Aghia Sophia” Children’s Hospital, Thivon & Papadiamantopoulou, PC 11527, Athens, Greece..First Department of PediatricsNational and Kapodistrian University of Athens, Medical School, “Aghia Sophia” Children’s Hospital, Thivon & PapadiamantopoulouAthensPC 11527Greece

Abstract

Lung abscess is a severe but rare complication among non-transplanted cystic fibrosis (CF) patients. <10 cases have been reported in the international literature so far and bacteria were considered the responsible pathogen. We present two cases of CF adolescent patients who developed lung abscess from A. fumigatus, critically revealed with chest Computed Tomography. In one patient, a thyroid abscess was additionally detected. Both patients presented with fever, not responding to antibiotic therapy. Microbial cultures and molecular testing aided detection of the pathogen. Both patients responded well to antifungal treatment.

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Keywords : Cystic fibrosis, Lung abscess, Thyroid abscess, Aspergillus fumigatus

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Vol 35 - N° 3

Article 101570- septembre 2025 Retour au numéro

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Aspergillus fumigatus lung abscess in two adolescents with cystic fibrosis - 09/07/25

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