Pathogenesis, animal models and pharmacological treatments of hyperuricemia: A systematic review - 04/02/26
, Lihong Liu ⁎ Abstract |
Hyperuricemia, a common metabolic disorder, arises primarily from excessive uric acid production or impaired excretion, resulting in abnormal elevation of uric acid in extracellular fluids and tissues. Sustained hyperuricemia is closely linked to the development of gout, kidney diseases, and cardiovascular disorders. To date, hyperuricemia pathogenesis remains incompletely elucidated, with key challenges in animal model selection, therapeutic drug characterization, and the development of emerging treatments. Notably, increasing research attention has focused on traditional Chinese medicine (TCM) has gained growing research interest due to its unique advantages in treating hyperuricemia via holistic regulation and multi-targeted mechanisms. This review synthesizes these key topics, aiming to inform in-depth investigations into hyperuricemia pathogenesis, animal model optimization, and the development of TCM-centered emerging treatment strategies.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
The overall image depicts the transition from pathological disorder to homeostatic recovery, echoing the review’s overview of hyperuricemia’s pathogenesis, the limitations of animal models, and integrated TCM-Western medicine treatment strategies. It also specifically highlights TCM’s potential in improving pathological conditions and reestablishing bodily balance. On the left side, elements such as dark clouds, lightning, monosodium urate (MSU) crystals, inflammatory factors, and pathological cells visually embody the pathological process of hyperuricemia. This process specifically includes the inflammatory cascade triggered by MSU crystal deposition and the subsequent damage to the body. On the right side, the Taiji symbol (representing traditional Chinese medicine, TCM), sunny surroundings, and healthy cells correspond to the multi-target regulatory effects of TCM (monomers, single herbs, and formulas) as outlined in the review.
The overall image depicts the transition from pathological disorder to homeostatic recovery, echoing the review’s overview of hyperuricemia’s pathogenesis, the limitations of animal models, and integrated TCM-Western medicine treatment strategies. It also specifically highlights TCM’s potential in improving pathological conditions and reestablishing bodily balance. On the left side, elements such as dark clouds, lightning, monosodium urate (MSU) crystals, inflammatory factors, and pathological cells visually embody the pathological process of hyperuricemia. This process specifically includes the inflammatory cascade triggered by MSU crystal deposition and the subsequent damage to the body. On the right side, the Taiji symbol (representing traditional Chinese medicine, TCM), sunny surroundings, and healthy cells correspond to the multi-target regulatory effects of TCM (monomers, single herbs, and formulas) as outlined in the review. Le texte complet de cet article est disponible en PDF.
Highlights |
• | Immune homeostasis imbalance is a key pathogenic mechanism of hyperuricemia. |
• | Standardized non-rodent animal models can enhance non-clinical research value. |
• | Traditional Chinese medicine possesses unique advantages in treating hyperuricemia. |
Keywords : Hyperuricemia, Pathogenesis, Animal models, TCM
Plan
Vol 195
Article 119011- février 2026 Retour au numéro
Article précédent
- Neuroendocrine signaling as a pathological seed for the female bias of Alzheimer’s disease and the concept of estrobolome
- Deepthi Rapaka, Arthur Saniotis, Monkgogi Thatayaone, Veera Raghavulu Bitra
- Exosome-derived microRNAs from stem cells from human exfoliated deciduous teeth (SHED): Emerging therapeutics for neurodegenerative disorders
- Leila Elyasi, Michalina Wężyk
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?