Adjunctive hyperbaric oxygen combined with surgery and antifungal therapy for the management of soft tissue mucormycosis: a case report and review of the literature - 06/02/26

Doi : 10.1016/j.mycmed.2026.101610

Pauline Kapustin ^a, Aline Munting ^a, Benoît Desgraz ^b, Etienne Menager ^b, Jérémy Brühlmann ^c, Jocelyn Corbaz ^d, Truong-Thanh Pham ^e,^f, Sylvain Meylan ^a, Daniel Wagner ^d, Yves Harder ^c, Frederic Lamoth ^a,^g,^⁎

^a Service of Infectious Diseases, Department of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

^b Subaquatic and Hyperbaric Medicine Unit, Emergency Service, Acute Medicine Department, Geneva University Hospitals, Geneva, Switzerland

^c Department of Plastic, Reconstructive and Aesthetic Surgery and Hand Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

^d Department of Orthopedics and Traumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

^e Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland

^f Division of Orthopaedics and Trauma Surgery, Geneva University Hospitals, Geneva, Switzerland

^g Institute of Microbiology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

^⁎ Corresponding author at: Infectious Diseases Service and Institute of Microbiology, Lausanne University Hospital, Rue du Bugnon 48, 1011 Lausanne, Switzerland. Infectious Diseases Service and Institute of Microbiology Lausanne University Hospital Rue du Bugnon 48 Lausanne 1011 Switzerland

Abstract

Soft tissue mucormycosis is a rare fungal infection that can develop on contaminated wounds. We report a case of Mucor circinelloides ankle infection in an immunocompetent man following a high-energy motorcycle accident, which has successfully been treated by surgery (multiple debridements, arthrodesis, soft tissue defect reconstruction with flap and skin graft), systemic antifungal therapy (initial liposomal amphotericin B followed by isavuconazole) and hyperbaric oxygen. This case highlights the therapeutic challenges and need for a multidisciplinary approach of such infection.

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Keywords : Mucorales, Isavuconazole, Osteomyelitis, Arthritis, Cutaneous mucormycosis

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Vol 36 - N° 1

Article 101610- mars 2026 Retour au numéro

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Adjunctive hyperbaric oxygen combined with surgery and antifungal therapy for the management of soft tissue mucormycosis: a case report and review of the literature - 06/02/26

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