Prevalence of sleep disorders in patients with bullous pemphigoid - 14/03/26

Doi : 10.1016/j.annder.2025.103464

M. Alqahtani ^a,^⁎ , M. Viguier ^b,^c, G. Chaby ^d, G. Jeudy ^e, C. Bedane ^f, M. Alexandre ^g, C. Picard-Dahan ^h, S. Duvert Lehembre ⁱ, C. Abasq ^j, G. Quéreux ^k,^l, H. Maillard ^m, J.L. Perrot ⁿ, C. Couzan ^o, A. Pham-Ledard ^p, V. Hebert ^a, P. Joly ^a

^a Department of Dermatology, Rouen University Hospital, Normandie University, Rouen, France

^b Dermatology Department, Robert Debré Hospital, Reims University, Reims, France

^c Champagne Ardenne University (URCA), Reims, France EA7509, IRMAIC, URCA, Reims, France

^d Dermatology Department, Amiens-Picardie Site, Nord University Hospital, Amiens, France

^e Dermatology Department, F.Mitterrand Dijon-Bourgogne University Hospital, Dijon, France

^f Dermatology Department, Dijon University Hospital, Dijon, France

^g Dermatology Department, Hôpital Avicenne Assistance Publique-Hôpitaux de Paris, Bobigny, France

^h Dermatology Department, Hôpital Bichat - Claude-Bernard, Paris, France

ⁱ Dermatology Department, Lille University Hospital, Lille, France

^j Dermatology Department, Brest University Hospital, Brest, France

^k Dermatology Department, Nantes University Hospital, Nantes, France

^l Nantes University, CIC 1413, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302, F-44000 Nantes, France

^m Dermatology Department, Le Mans General Hospital, Le Mans, France

ⁿ Dermatology-Allergy-Oncology Department, Nord Saint-Étienne University Hospital, Saint-Priest-en- Jarez, France

^o Dermatology Department, Nord Saint-Étienne University Hospital, Saint-Priest-en-Jarez, France

^p Dermatology Department, Bordeaux University Hospital and University of Bordeaux, Bordeaux, France

^⁎ Corresponding author.

Abstract

Background

Alleviating sleep disturbances is a key therapeutic goal in pruritic dermatoses. However, sleep disturbance remains under-investigated in patients with bullous pemphigoid (BP), despite contributing to exhaustion in older adults and potentially increasing disease morbidity.

Objectives

To estimate the prevalence and severity of insomnia in BP patients, and examine its correlation with disease activity, self-rated pruritus, and quality of life (QoL).

Method

A national, multicenter, controlled study in 61 BP patients and 61 age- and sex-matched controls. Insomnia severity was assessed via the Insomnia Severity Index (ISI), BP activity via the Bullous Pemphigoid Disease Area Index (BPDAI), and QoL via the Autoimmune Bullous Disease Quality of Life (ABQOL) and ItchyQoL scores. Pruritus severity was rated using a numerical scale (NRS-pruritus). All assessments were repeated after one month of treatment.

Results

Significant sleep disorders (ISI ≥ 15) were observed in 34.4 % of cases and 8.5 % of controls (RR: 4.04; 95 % CI: 1.64–10.06; p = 0.0025). Significant sleep disorder was associated with higher ItchyQoL, ABQOL, and NRS-pruritus scores. However, the ItchyQoL score was the only independent factor (OR = 1.13; 95 % CI: 1.02–1.25). After one month of treatment, significant insomnia decreased by 56.2 % compared to baseline (p < 0.001).

Conclusion

BP is associated with a four-fold risk of insomnia compared to age- and sex-matched controls. Screening for insomnia and promoting sleep quality should be part of BP treatment strategies.

Le texte complet de cet article est disponible en PDF.

Keywords : Bullous pemphigoid, Autoimmune blistering, Skin diseases, Sleep disturbances

Plan

Clinical features of case and control patients

Levels and relative risk of insomnia

Factors associated with sleep disorder

Pre-to-post treatment changes in the study parameters

Correlations between scores in pre- and post-treatment periods and change over time

Discussion

Export

Vol 153 - N° 1

Article 103464- mars 2026 Retour au numéro

Article précédent

Evolution of the sentinel lymph node procedure following the approval of adjuvant anti-PD-1 therapy for stage IIB and IIC melanoma: A multicenter study from RICMEL database
M. Deriouich, R. Levard, T. Tagmouti, D. Sanogo, J. Cassecuel, A. Khammari, G. Quereux, A. Dompmartin, B. Dreno, J.-M. L’Orphelin

| Article suivant

Evaluation of dermatology care pathways incorporating store-and-forward telemedicine: A retrospective cohort study
E. Demoulins, L. Martin, Y. Le Corre, T. Bizouard, C. Jacobzone-Leveque, C.-A. de Salins, K. Chassain

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Prevalence of sleep disorders in patients with bullous pemphigoid - 14/03/26

Abstract

Background

Objectives

Method

Results

Conclusion

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL