The aim of this qualitative study was to examine patient narratives concerning “sensing the presence of the deceased experiences” (SPE). Fourteen people who attended psychotherapy sessions at a psychology service in southern Italy took part in semi-structured interviews developed using interpretative phenomenological analysis. The meaning making of SPEs was analyzed in the context of a multimethod assessment procedure addressing psychopathology, trauma, dissociation, the “ego–world” boundary, and anomalous experiences, while observations from the psychotherapeutic process—a combined cognitive and eye movement desensitization and reprocessing (EMDR) procedure—were also used. This study found that patients' sense of presence experiences were generally spiritual, interactive, and positive, benefiting personality, mood, and mental health. Distressing experiences were linked to feelings of responsibility for deceased loved ones and the lack of a belief system for integrating these experiences. This article also includes two short clinical vignettes illustrating how the EMDR technique can be effectively applied to positive SPEs in patients suffering from complex trauma disorder and unresolved loss. Applying bilateral stimulation to memories of positive hallucinations helped in resolving symptoms by integrating adaptive memory networks associated with the deceased into the self. The conclusion is drawn that a sense of presence experience can be the product of a pathological dissociative process as well as the expression of a religious meaning-making system underlining normal, beneficial, and potentially healing dissociative processes. The study’s limitations and cultural specificity are outlined at the end.