Performance of the glucose-potassium ratio as a biomarker of mortality in children with severe traumatic brain injury - 14/04/26
, José Roberto Tude Melo b , Caio Vinícius de Almeida Chaves a , Luiza Malheiros Montagna a , Júlia Calviello Giordano a , Isadora Araújo Santos Lobo a , Jean Gonçalves de Oliveira b , José Carlos Esteves Veiga b Highlights |
• | GPR shows moderate predictive accuracy for mortality in pediatric severe TBI |
• | GPR < 50 demonstrates a high negative predictive value (91%) |
• | GPR < 50 identifies children at lower in-hospital mortality risk |
• | Simple, low-cost GPR calculation supports early risk stratification |
• | Study reinforces GPR as an additional prognostic biomarker in severe TBI |
Abstract |
Purpose |
Traumatic brain injury (TBI) causes changes in the blood level of biomarkers due to mechanical cell membrane disruption and excitation of membrane potential. The scope of this study was to identify the performance of the glucose-potassium ratio (GPR) as a predictive biomarker of mortality in children with severe TBI.
Methods |
Cross-sectional analytical study carried out in a Brazilian trauma reference center through the review of consecutive medical records of children with severe TBI hospitalized between 2016 and 2023. We analyzed blood glucose (BG) and potassium values obtained in the first 24 h after TBI. GPR was calculated retrospectively by dividing BG values by potassium values. The performance of GPR as a predictor of mortality was analyzed using the receiver operating characteristic (ROC) curve.
Results |
We included 40 children with severe TBI with a mean age of 9 years (SD ± 5.5 years). Hyperglycemia was observed in 33% and hypokalemia in 58% of the patients, and GPR ≥ 50 was found in 43% of the patients. With a mortality rate of 23%, the ROC showed an area under the curve (AUC) of 0.71, and the cutoff point of 50 in GPR showed a negative predictive value of 91%.
Conclusion |
The area under the ROC curve (AUC) of 0.71 indicates a moderate performance of GPR as a predictive biomarker of mortality in children with severe TBI, with the cutoff point of 50 allowing the identification of patients with a lower risk of death.
Le texte complet de cet article est disponible en PDF.Keywords : Traumatic brain injury, Biomarkers, Glucose, Potassium, Mortality, Pediatrics
Abbreviations : TBI, GPR, BG, ROC, AUC, SD, GCS, PED, CT, IQR, OR, PPV, NPV, ATP, TNF-α, IL-6
Plan
Vol 72 - N° 3
Article 101812- mai 2026 Retour au numéro
Article précédent
- Cauda equina neuroendocrine tumors: an 11-year retrospective report on clinicopathological characteristics and postoperative recurrence
- Marvin R. Tsopmene Dongmo, Laetitia LE Petit, Jean-Rodolphe Vignes, Thomas Wavasseur, Guillaume Chotard, Edouard Gimbert, Vincent Jecko
- Review of treatment modalities and clinical outcome of giant saccular anterior inferior cerebellar artery aneurysms
- Andreas Theofanopoulos, Ben Waldau, Marc Ronald Schneider, Katharina Faust, Sajjad Muhammad
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?