Association of dietary index for gut microbiota with premature and all-cause mortality: A mediation analysis of biological age - 24/04/26
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Graphical abstract |
Highlights |
• | Elevated DI-GM scores correlate with a lower premature death and overall mortality. |
• | Each one-point rise in DI-GM lowers premature death risk by 9% and all-cause mortality risk by 10%. |
• | PhenoAge, KDM age, and homeostatic dysregulation partially mediate the relationship between DI-GM and mortality. |
Abstract |
Background |
The intestinal microbiota critically modulates physiological status and is shaped by nutritional intake. This research explored the correlation between the dietary index for gut microbiota (DI-GM) and premature death and all-cause mortality, focusing on the mediating effect of biological age.
Methods |
The longitudinal study drew upon information gathered from the National Health and Nutrition Examination Survey (NHANES) spanning 2007–2018, with mortality data linked through 2019. DI-GM scores derived from nutritional values. Premature death and all-cause mortality were the primary endpoints. Biological age was assessed using PhenoAge (PA), the Klemera-Doubal Method (KDMAge), and homeostatic dysregulation (HD). The correlation between DI-GM and mortality was analyzed through Kaplan-Meier curves, Cox regression, smooth curve fitting, subgroup analysis, and mediation analysis.
Results |
The study comprised 15,810 participants (mean age: 47.0 ± 15.7 years; 49.3% male). Multivariable Cox regression revealed that each DI-GM point rise correlated with 9% fewer premature deaths and 10% lower total mortality. Smooth curve fitting showed a clear inverse linear correlation between DI-GM scores and both premature and total mortality, consistent across subgroups. Mediation analysis revealed that biological age partially mediates this association.
Conclusion |
Elevated DI-GM scores were associated with a lower premature death and all-cause mortality, with biological aging serving as a significant mediator in this relationship.
Le texte complet de cet article est disponible en PDF.Abbreviation : BMI, CDC, CHD, CI, COPD, DI-GM, HbA1c, HD, HR, KDM, MASLD, MetS, NCHS, NHANES, PA, PAG, PCS, SCFAs, TMAO
Keywords : Premature death, All-cause mortality, Dietary index for gut microbiota, Biological age
Plan
Vol 30 - N° 6
Article 100861- juin 2026 Retour au numéro
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