Phenotyping of mild behavioral impairment domains in multi-regional dementia-free older adults of Chinese ethnicity: impulse dyscontrol as the leading domain - 09/05/26
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Highlights |
• | Impulse dyscontrol is the most prevalent MBI domain across multi-regional cohorts of older adults of Chinese ethnicity. |
• | MBI domains are associated with worse longitudinal cognitive outcomes. |
• | NPI demonstrates good alignment with MBI-C in identifying MBI domains. |
• | Symptom clustering and overlap across MBI domains should be explored in future studies. |
Abstract |
Background |
Mild behavioral impairment (MBI) is an early neurobehavioral marker of dementia, yet MBI domain patterns remain underexplored among populations of Chinese ethnicity. This study aimed to characterize MBI domain phenotypes by examining the prevalence of MBI domains and identifying the leading domain across multi-regional cohorts of dementia-free older adults of Chinese ethnicity.
Methods |
Data from three previously unpublished datasets (Hangzhou community cohort, China Longitudinal Aging Study and Singapore memory clinic cohort) and three published studies were integrated to estimate the MBI domain prevalence, measured by the Neuropsychiatric Inventory (NPI) and/or MBI-Checklist (MBI-C), through a random-effects meta-analysis. Within the Hangzhou cohort, cross-instrument consistency was evaluated. Exploratory analyses were performed in the Singapore cohort on associations between MBI domains and incident dementia.
Results |
Among 1817 participants, impulse dyscontrol was the most prevalent MBI domain, followed by affective dysregulation and decreased motivation, consistently across instruments and cognitive status. In the exploratory longitudinal analyses, impulse dyscontrol was associated with a greater likelihood of incident dementia (HR = 5.05, 95%CI = 2.92 – 8.73).
Conclusions |
Impulse dyscontrol was the leading MBI domain among older adults of Chinese ethnicity, with potential clinical relevance for early identification and dementia risk stratification.
Le texte complet de cet article est disponible en PDF.Keywords : Mild behavioral impairment, Neuropsychiatric symptoms, Prevalence, Neuropsychiatric inventory, Mild behavioral impairment-checklist, Mild cognitive impairment
Plan
Vol 13 - N° 7
Article 100589- août 2026 Retour au numéro
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