The Severe Anaphylaxis in France nEtwork (SAFE) project: a new anaphylaxis registry - 26/05/26

Doi : 10.1016/j.jahd.2026.100069

Guillaume Pouessel ^a,^b,^c,⁎ , Flore Amat ^d, Luc Colas ^e, Pascal Demoly ^f, Sylvie Leroy ^g, Paul-Michel Mertes ^h, Catherine Neukirch ⁱ, Céline Palussière ^j, Dominique Sabouraud-Leclerc ^k, Charles Tacquard ^h, Luciana Kase Tanno ^f, Joana Vitte ^l

^a Department of Paediatrics, Children’s Hospital, Roubaix, France

^b Paediatric Pulmonology and Allergy Department, Jeanne de Flandre Hospital, Lille University Hospital (CHU), Lille, France

^c Lille University, ULR 2694: METRICS, F-59000, Lille, France

^d INSERM UMR 1018, Integrative Respiratory Epidemiology, Villejuif, France, Department of Pediatric Pulmonology and Allergology, Robert Debré Hospital, Paris, France

^e Nantes University Hospital (CHU), Nantes University, Dermatology clinic, Allergology Transversal Platform, Nantes, France, Nantes University, Nantes CHU, INSERM, Centre for Research in Transplantation and Translational Immunology, UMR 1064, F-44000, Nantes, France

^f Division of Allergy, Department of Pulmonology, Allergy and Thoracic Oncology, University Hospital of Montpellier, Montpellier, France, Desbrest Institute of Epidemiology and Public Health, UMR 1318 University of Montpellier - INSERM, France, WHO Collaborating Centre on Scientific Classification Support, Montpellier, France

^g University of the Côte d'Azur, IHU RespirERA, Nice University Hospital (CHU), Pulmonology and Allergy Department, Pasteur Hospital, Nice, France, CNRS, UMR 7275 Institute of molecular and cellular pharmacology, Sophia Antipolis, Nice, France

^h Department of anaesthesia and Intensive Care, Strasbourg University Hospital, Strasbourg France, UMR-S1255, Strasbourg, France

ⁱ Pneumology Allergology and Transplantation Department, APHP, Bichat Hospital, Paris, France, Inserm UMR 1152, Paris Cité University, Paris, France

^j Allergy medical office, 33150 Cenon, France

^k General and Specialized Paediatrics Department, American Hospital, Reims University Hospital Centre, Reims, France

^l Immunology Department, INSERM UMR-S 1250 P3CELL, CHU Reims, University of Reims Champagne-Ardenne, Reims, France

^⁎ Corresponding author.

connectez-vous ou créez un compte

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Sous presse. Manuscrit accepté. Disponible en ligne depuis le Tuesday 26 May 2026

Abstract

Health registries improve our knowledge, support optimising care organisation and quality, and support the implementation of personalised medicine. While many registries collect data in the field of allergy and immunology worldwide, only few registries are dedicated to anaphylaxis.

Despite a growing scientific interest in anaphylaxis over the past decade, current knowledge on severe anaphylaxis is insufficient, with many unresolved questions regarding risk factors, impact of cofactors, specific aspects in childhood, details related to trigger and the most appropriate therapeutic strategies. There is a clear need for health registries dedicated to severe anaphylaxis to address these gaps.

This article aims first to present the rationale for creating a new registry dedicated to severe anaphylaxis by defining and describing health registries and related challenges in the field of anaphylaxis worldwide and in France, identifying knowledge gaps in severe anaphylaxis, and second to present the objectives of the new French anaphylaxis registry, named Severe Anaphylaxis in France nEtwork (SAFE).

In 2026, the French Professional Council for Allergology, in partnership with key allergy stakeholders in France, notably the French Allergy Society, will inaugurate the SAFE registry in order to provide inputs on severe anaphylaxis, integrating all involved caregivers, including emergency care, anaesthesia and intensive care, paediatrics, research structures and patient associations.

Le texte complet de cet article est disponible en PDF.

Keywords : allergy, anaphylaxis, network, registry, severity