Health registries improve our knowledge, support optimising care organisation and quality, and support the implementation of personalised medicine. While many registries collect data in the field of allergy and immunology worldwide, only few registries are dedicated to anaphylaxis. Despite a growing scientific interest in anaphylaxis over the past decade, current knowledge on severe anaphylaxis is insufficient, with many unresolved questions regarding risk factors, impact of cofactors, specific aspects in childhood, details related to trigger and the most appropriate therapeutic strategies. There is a clear need for health registries dedicated to severe anaphylaxis to address these gaps. This article aims first to present the rationale for creating a new registry dedicated to severe anaphylaxis by defining and describing health registries and related challenges in the field of anaphylaxis worldwide and in France, identifying knowledge gaps in severe anaphylaxis, and second to present the objectives of the new French anaphylaxis registry, named Severe Anaphylaxis in France nEtwork (SAFE). In 2026, the French professional council for allergy, in partnership with key allergy stakeholders in France, notably the Société française d'allergologie (the French allergy society), will inaugurate the SAFE registry in order to provide inputs on severe anaphylaxis, integrating all involved caregivers, including emergency care, anaesthesia and intensive care, paediatrics, research structures and patient associations.