The International Trauma Interview (ITI) can guide clinicians in assessing posttraumatic stress disorder (PTSD) and complex PTSD. Emerging evidence supports the ITI’s validity, but its clinical utility in routine practice remains underexplored. The aim of this study was to investigate clinician-rated utility of the ITI across three specialised PTSD clinics treating different trauma-affected populations. We collected qualitative focus group data across all clinics. Systematic quantitative data on interview duration and clinician-rated response validity for 100 interviews were collected at two clinics only. Thematic analysis with mixed-methods integration showed that from a clinician perspective, 1) the ITI’s appropriateness for clinical practice is anchored in its thoroughness, 2) time constraints challenge its accessibility, 3) client- and wording-related factors influence its practicability, and 4) its acceptability among clinicians is predominantly positive. Overall, the ITI holds valuable potential for clinical practice, but considering how to compensate for the time-consuming implementation is vital for future clinical use. To enhance the clinical utility of the ITI, we discuss its utility beyond diagnostics, adopting a more flexible interview format, examining wording and translations to enhance validity and flow, ensuring adequate clinician training, and exploring clients’ perceptions of the ITI. In conclusion, our study revealed both advantages and challenges influencing clinicians’ perceptions of the clinical utility of the ITI. We recommend further research on the ITI’s clinical utility to support its thoughtful integration into routine trauma-focused practice.