Is endometrial receptivity in women with endometriosis negatively affected? Insights from IVF frozen embryo transfer cycles - 08/09/26
, Roberta Bellinghieri a, Marco Reschini a, Paola Viganò a, Pietro Santulli b, c, d
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Highlights |
• | Use of matched design between cases and controls for age and number and quality of blastocysts obtained that minimizes the influence of ovarian and anatomical factors associated with endometriosis; |
• | Cumulative clinical pregnancy rates and cumulative live birth rates did not differ between patients with and without endometriosis; |
• | Endometriosis does not significantly impair endometrial receptivity. |
Abstract |
Introduction |
Endometriosis is a major cause of infertility, and Assisted Reproductive Techniques (ART) represent an effective approach for managing infertility associated with this condition. Because ART cycles allow direct evaluation of implantation outcomes, they provide a useful framework for assessing the specific impact of endometriosis on endometrial receptivity.
Material and methods |
In this retrospective matched case-control study, we aimed to investigate the effect of endometriosis on endometrial receptivity using a design that minimizes the influence of ovarian and anatomical factors associated with the disease. A total of n = 195 women with peritoneal, ovarian and/or deep endometriosis were included and matched 1:1 with controls according to age and the number and morphological quality of cryopreserved blastocysts. All participants underwent a freeze-all ART cycle between September 2016 and September 2018 at the Reproductive Medicine Unit of Cochin Hospital and were evaluated according to the Core Outcome Measures for Infertility Trials recommendations.
Results |
The cumulative clinical pregnancy rate was similar in women with and without endometriosis (62% vs 61%, crude OR 1.02, 95% CI 0.68 to 1.54; P = 0.92). After adjustment for variables that differed between groups (BMI, total number of retrieved oocytes and fertilization method), the OR was 1.25 (95% CI 0.79 to 2.00; P = 0.34). The cumulative live birth rate was also similar between groups (48% vs 49%, P = 0.84).
Conclusions |
Our findings suggest that, in affected patients, endometriosis does not significantly impair endometrial receptivity.
Le texte complet de cet article est disponible en PDF.Key-words : endometriosis, endometrial receptivity, implantation rate, pregnancy rates, ART outcomes
Abbreviations : AFC, AMH, ART, ASRM, BMI, CHU, CI, CLEP, COX-2, E2, EE, ESHRE, FSH, FET, GnRH, HUPC, ICM, ICSI, IVF, LNG, OHSS, OR, P, TE
Plan
| Paola Viganò is one of the Editors in Chief of Journal of Endometriosis and Uterine Disorders |
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| Pietro Santulli is a member of the editorial board of Journal of Endometriosis and Uterine Disorders |
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