What somatic-lineage analysis can - and cannot - show about the cellular ancestry of endometriosis lesions - 17/09/26
Doi : 10.1016/j.jeud.2026.100187
Francisco J. Garcini ⁎ 
Northwest Allied Physicians, Northwest Medical Center, 6200 N La Cholla Blvd, Tucson, Arizona 85741, United States of America
⁎ Corresponding author.
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Highlights |
• | Validated passenger variants can provide positive evidence of cellular ancestry. |
• | Common uterine–lesion ancestry does not establish route, timing, or direction. |
• | Failure to find a uterine match does not establish a developmental-rest origin. |
• | Epithelial and stromal compartments require separate lineage analyses. |
• | Incomplete sampling may be mistaken for etiologic heterogeneity. |
Keywords : somatic mutation, clonal evolution, developmental rest
Plan
© 2026
Publié par Elsevier Masson SAS.
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