Association of plasma growth differentiation factor 15 with wake after sleep onset in mild cognitive impairment - 24/09/26
, Takuya Ataka a, Kaori Sumi a, Yosuke Takeuchi a, Yuko Akiyoshi a, Fusa Matsuzaki a, Hirofumi Hirakawa b, Etsuro Matsubara a, Noriyuki Kimura a
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Highlights |
• | Greater WASO was associated with higher plasma GDF-15 in older adults with MCI. |
• | A 10-min increment in WASO corresponded to 10.6% higher plasma GDF-15. |
• | Adding WASO to baseline covariates increased model R 2 by 6.3 percentage points. |
• | Total sleep time and amyloid burden showed no clear relationship with plasma GDF-15. |
Abstract |
Objectives |
Circulating growth differentiation factor 15 (GDF-15) concentrations increase with age and are elevated in chronic diseases, but evidence regarding habitual wake after sleep onset (WASO) and circulating GDF-15 remains limited. We therefore examined the cross-sectional association between plasma GDF-15 and wearable-estimated WASO in older adults with mild cognitive impairment (MCI).
Design |
Cross-sectional biomarker analysis of first-year data from a prospective community-based cohort.
Setting |
USUKI study, Usuki, Oita, Japan.
Participants |
118 community-dwelling adults aged ≥65 years with MCI.
Intervention |
None.
Measurements |
We measured plasma GDF-15 concentrations using an enzyme-linked immunosorbent assay. We averaged wearable sleep data across repeated assessments. WASO was the primary measure of sleep continuity; total sleep time (TST) was examined as a measure of sleep quantity; and amyloid burden was assessed using 11 C-Pittsburgh compound B PET (PiB-PET) global standardized uptake value ratio (SUVR) and PiB positivity.
Results |
The median plasma GDF-15 concentration was 1,230.8 pg/mL (IQR, 956.6–1,590.5), and the median WASO was 18.4 min (IQR, 11.6–27.5). After adjustment for age, sex, education, diabetes mellitus, and estimated glomerular filtration rate, each 10-min increment in WASO was associated with a 10.6% higher GDF-15 concentration (95% CI, 4.8%–16.8%; p < 0.001). TST and PiB-PET global SUVR were not significantly associated with GDF-15, and the proportion of PiB-positive participants did not differ across GDF-15 tertiles.
Conclusion |
In older adults with MCI, poorer habitual nocturnal sleep continuity, as reflected by greater wearable-estimated WASO, was associated with higher plasma GDF-15 concentrations after multivariable adjustment.
Le texte complet de cet article est disponible en PDF.Abbreviations : ADAS-Cog, CI, eGFR, FDG-PET, FDR, GDF-15, HC3, IQR, LPA, MCI, METs, MMSE, MoCA-J, MRI, MVPA, PET, PiB, PiB-PET, STROBE, SUVR, TST, WASO
Keywords : Growth differentiation factor 15, Wake after sleep onset, Mild cognitive impairment, Wearable device, Sleep continuity
Plan
Vol 30 - N° 11
Article 100991- novembre 2026 Retour au numéro
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