From ACLF to recompensation: the evolving understanding of the natural history of cirrhosis - 04/11/26
Doi : 10.1016/j.clinre.2026.102964
Filoména CONTI 1, Marc BILODEAU 2, Yvon CALMUS 3, ⁎ 
1 Department of Hepatology, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France
2 Liver Unit, Centre hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada
3 Centre de Spécialités Médicales Odon Vallet, Paris, France
⁎ Corresponding author.
Sous presse. Manuscrit accepté.
Disponible en ligne depuis le Wednesday 04 November 2026
HIGHLIGHTS |
• | What is already known on this subject? Cirrhosis trajectories vary; ACLF and recompensation extend the traditional binary model. |
• | What are the new findings? Prior decompensation marks higher risk; biochemical criteria alone may miss high-mortality patients. |
• | How might it impact on clinical practice in the foreseeable future? Integrating clinical history and extrahepatic organ dysfunction may improve risk assessment. |
Plan
| English-language editing was performed with the assistance of artificial intelligence. |
© 2026
Publié par Elsevier Masson SAS.
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