Interpersonal functioning is increasingly recognized as a relevant domain in the understanding of psychological distress and relational vulnerability. The present cross-sectional study examined whether specific interpersonal styles statistically accounted for the association between interpersonal reactivity and global psychological symptomatology in a non-clinical sample. A total of 250 participants completed self-report measures assessing interpersonal reactivity (Interpersonal Reactivity Index), interpersonal problems (Inventory of Interpersonal Problems-32), and psychological symptoms (Brief Symptom Inventory-53). Two parallel multiple mediation models were tested using the Global Severity Index of the Brief Symptom Inventory. In the first model, Vindictive/Self-Centered and Socially Inhibited interpersonal styles emerged as indirect effects. In the second model, the Self-Sacrificing and Nonassertive interpersonal styles emerged as a significant indirect effects. These findings suggest that maladaptive interpersonal patterns may help clarify how interpersonal reactivity is associated with psychological distress in non-clinical populations. Overall, the study highlights the relevance of interpersonal styles in the association between interpersonal reactivity and symptom expression within an integrative framework.