Systematic reviews of treatment for chronic inflammatory demyelinating neuropathy - 27/03/09
R.-A.-C. Hughes
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Systematic reviews of treatment for chronic inflammatory demyelinating neuropathy |
Chronic inflammatory demyelinating polyradiculoneuropathies include chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraprotein-associated demyelinating neuropathy. This review summarises the evidence from randomised controlled trials (RCTs) for the treatment of these conditions. It leads to the conclusions that: 1) steroids are beneficial in CIDP but not MMN and their efficacy in paraproteinaemic demyelinating neuropathy (PDN) is uncertain; 2) intravenous immunoglobulin (IVIg) produces short-term benefit in CIDP, MMN and IgM PDN. Its effect in IgG or IgA PDN has not been tested in RCTs; 3) plasma exchange (PE) also produces short-term benefit in CIDP and IgG or IgA PDN but probably not in MMN; 4) there is almost no information from RCTs concerning the possible benefits of immunosuppressive agents; and 5) volunteers are needed to write Cochrane systematic reviews of IVIg for MMN and of interventions for PDN associated with IgG and IgA.
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© 2002 Elsevier Masson SAS. Tous droits réservés.
Vol 158 - N° 123
P. 32-36 - décembre 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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