Depression is not a transient feeling of resentment, it is a disease that significantly impairs daily life. It is result of the imbalance of chemical substances in the brain, with an important role of heritage, stress and lifestyle.

This paper presents a case of a patient who has had two hospital treatment in a span of 25 years, and who was treated with antidepressants both older and the newer generation, without therapeutic response. Therapeutic response was achieved with application of ECT after the first hospitalization in 1987 and remission lasted for 25 years without treatment. After 25 years, when the disease re-emerged, and the number of antidepressants on the market has increased, patient’s recovery was again absent, even she was treated with newer antidepressant. Residual symptoms are very severe, and are essential for social and professional functions.

Today, despite a number of antidepressant available, 30–50% of all patients still do not have satisfactory response to initial treatment.