P02-355 - Tardive dyskinesia induced by quetiapine and confirmed by a Dat-scan - 05/05/11
Résumé |
Background |
Tardive dyskinesia is a serious side effect of antipsychotics’ activity. Imaging of the dopamine transporter could demonstrate the possible involvement of dopaminergic pathway in the appearance of tardive dyskinesia.
Methods/results |
We report a case with paranoid schizophrenia and tardive dyskinesia symptoms. A first trial with quetiapine improved TD symptoms while an increase of its dose after a relapse of the underlying disease deteriorated the TD symptoms. Following that, sertindole was initiated which led to improvement of both psychotic and TD symptoms. A DAT scan showed physiologic distribution in the basal ganglia. Six months later after a serious cardiac syncope, sertindole was discontinued. Quetiapine was then started which led again to TD symptoms. A second DAT scan showed decreased dopamine transporter uptake in the area of basal ganglia.
Conclusion |
We conclude that decreased dopamine transporter uptake seemed to associate with the deterioration of TD.
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Vol 26 - N° S1
P. 951 - 2011 Retour au numéro
Article précédent
- P02-354 - Brain structural abnormalities in first episode psychosis: A multimodal analysis
- S. Rigucci, A. Comparelli, A. De Carolis, M.C. Rossi-Espagnet, E. Ambrosi, G. Kotzalidis, A. Bozzao, S. Ferracuti, P. Girardi, R. Tatarelli
- P02-356 - The relationship between gray matter changes in schizophrenia patients and the number of psychotic episodes
- G. Rubeša, R. Antulov, A. Ružić Baršic, J. Lerga, D. Miletić
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