P02-357 - In vivo molecular imaging reveals distinct distributions of the serotonin transporter, the major inhibitory and excitatory serotonin receptors - 05/05/11
Résumé |
Introduction |
Based on evidences in molecular neuroimaging, postmortem and genetic studies, impaired serotonergic neurotransmission has been implicated with affective disorders. Moreover, a growing number of evidences showed strong interrelations within the serotonergic system suggesting a common mechanism in the modulation of receptor and transporter densities.
Objective |
Here we directly investigated the regional expression of the 5-HT1A, 5-HT2A and 5-HTT using PET and the three highly selective and specific radioligands [carbonyl-11C]WAY-100635, [18F]Altanserin and [11C]DASB in healthy subjects.
Methods |
A total of 55 healthy subjects (5-HT1A: 36 subjects, 18 males, age=26.0±4.9; 5-HT2A: 19 subjects, 11 males, age=28.2±5.9; 5-HTT: 8 males, age=28.12±3.6) were included in this study. Binding potential (BPND) values were quantified according to the AAL parcellation scheme.
Results |
BPND values averaged over both hemispheres ranged from 0.40–6.35 for the 5-HT1A receptor; 0.01–2.01 for the 5-HT2A receptor and 0.09–2.05 for the 5-HTT, respectively. There was a specific topological pattern according to the ratio between the 5-HT1A, 5-HT2A receptors and 5-HTT (“fingerprints”).
Conclusions |
Such information can be essential for detecting potential local alterations in the ratio between different binding proteins on a network level in pathological conditions.
Moreover, these data might provide further insight in area-specific effects of frequently prescribed selective serotonin re-uptake inhibitors (SSRI):
1) | due to the distinct local receptor and transporter availability; |
2) | SSRI application alters the postsynaptic receptor expression and thus; |
3) | leads to a modified interaction of inhibitory and exhibitory receptors. |
Vol 26 - N° S1
P. 953 - 2011 Retour au numéro
Article précédent
- P02-356 - The relationship between gray matter changes in schizophrenia patients and the number of psychotic episodes
- G. Rubeša, R. Antulov, A. Ružić Baršic, J. Lerga, D. Miletić
- P02-358 - Prediction error signal correlates with fluid intelligenceand dopamine synthesis across the lifespan
- F. Schlagenhauf, M. Rapp, Q. Huys, L. Deserno, A. Beck, J. Kalbitzer, Y. Kumakura, H.-G. Buchholz, M. Plotkin, A. Heinz
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