Congenital Hypothyroidism with a Delayed Thyroid-Stimulating Hormone Elevation in Very Premature Infants: Incidence and Growth and Developmental Outcomes - 02/08/11
Reprint requests: Dr Chanika Phornphutkul, MD, The Warren Alpert Medical School of Brown University, Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, 593 Eddy Street, Providence, RI 02903.Abstract |
Objective |
To test the hypothesis that very low birth weight (VLBW) and extremely low birth weight (ELBW) infants have an increased incidence of congenital hypothyroidism (CH) with a delayed thyroid-stimulating hormone (TSH) elevation and that the outcomes of these infants are similar to control infants.
Study design |
Retrospective analysis of newborn thyroid screening data for 92 800 live births in Rhode Island to identify CH with a delayed TSH elevation. Developmental, growth, and endocrine outcomes of the index cases were assessed at 18 months corrected age.
Results |
CH with a delayed TSH elevation occurred in 1 in 58 ELBW, 1 in 95 VLBW, and 1 in 30 329 infants weighing ≥1500 grams (P < .0001). The incidence of head circumference <10th percentile was higher in VLBW infants with CH associated with a delayed TSH elevation (P < .05), and the mean head circumferences, weights, lengths, and developmental scores were similar to matched control infants. Three infants received short-term levothyroxine replacement.
Conclusions |
The incidence of CH with a delayed TSH elevation was higher in ELBW and VLBW infants compared with infants weighing ≥1500 grams. The outcomes of these infants were comparable with matched control infants.
Le texte complet de cet article est disponible en PDF.Mots-clés : CH, ELBW, NBS, TSH, T4, VLBW
Plan
| Supported by the New England Regional Genetics Group (NERGG), University of New Hampshire (grant PZ09030). The authors declare no conflicts of interest. |
Vol 158 - N° 4
P. 538-542 - avril 2011 Retour au numéro
Article précédent
- Clinical Monitoring Guidelines for Congenital Hypothyroidism: Laboratory Outcome Data in the First Year of Life
- Bharti Balhara, Madhusmita Misra, Lynne L. Levitsky
- Early Changes in Plasma Amino Acid Concentrations during Aggressive Nutritional Therapy in Extremely Low Birth Weight Infants
- Cynthia Liudmilla Blanco, Alice Kim Gong, Belinda Kay Green, Alison Falck, John Schoolfield, Edward A. Liechty
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