Associations among maternal childhood socioeconomic status, cord blood IgE levels, and repeated wheeze in urban children - 03/08/11
Reprint requests: Rosalind J. Wright, MD, MPH, Channing Laboratory, Harvard Medical School, 181 Longwood Dr, Boston, MA 02215.Abstract |
Background |
Independent of current socioeconomic status (SES), past maternal SES might influence asthma outcomes in children.
Objective |
We examined associations among the mother’s SES in the first 10 years of her life (maternal childhood SES), increased cord blood IgE levels (upper 20% [1.37 IU/mL]), and repeated wheeze (≥2 episodes by age 2 years) in an urban pregnancy cohort (n = 510).
Methods |
Data on sociodemographics, discrimination, financial strain, community violence, interpersonal trauma, and other negative events were obtained prenatally. Prenatal household dust was assayed for cockroach and murine allergens, and traffic-related air pollution was estimated by using spatiotemporal land-use regression. Maternal childhood SES was defined by parental home ownership (birth to 10 years). Maternally reported child wheeze was ascertained at 3-month intervals from birth. Using structural equation models, we examined whether outcomes were dependent on maternal childhood SES directly versus indirect relationships operating through (1) cumulative SES-related adversities, (2) the mother’s socioeconomic trajectory (adult SES), and (3) current prenatal environmental exposures.
Results |
Mothers were largely Hispanic (60%) or black (28%), 37% had not completed high school, and 56% reported parental home ownership. When associations between low maternal childhood SES and repeated wheeze were examined, there were significant indirect effects operating through adult SES and prenatal cumulative stress (β = 0.28, P = .003) and pollution (β = 0.24, P = .004; P value for total indirect effects ≤ .04 for both pathways). Low maternal childhood SES was directly related to increased cord blood IgE levels (β = 0.21, P = .003). Maternal cumulative adversity (interpersonal trauma) was also associated with increased cord blood IgE levels (β = 0.19, P = .01), although this did not explain maternal childhood SES effects.
Conclusion |
Lower maternal childhood SES was associated with increased cord blood IgE levels and repeated wheeze through both direct and indirect effects, providing new insights into the role of social inequalities as determinants of childhood respiratory risk.
Le texte complet de cet article est disponible en PDF.Key words : Childhood socioeconomic status, intergenerational, cord blood IgE, inner-city, childhood wheeze, structural equation models, life course
Abbreviations used : IPT, MUP, SEM, SES
Plan
| The Asthma Coalition on Community, Environment, and Social Stress study is funded by grants R01 ES10932, U01 HL072494, and R01 HL080674 (R.J.W., principal investigator). M. J. Sternthal was supported by grant T32-ES07069-29 and the Leaves of Grass Foundation. |
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| Disclosure of potential conflict of interest: B. A. Coull receives research support from the National Institutes of Health and the US Environmental Protection Agency. R. J. Wright receives research support from the National Institutes of Health. The rest of the authors have declared that they have no conflict of interest. |
Vol 128 - N° 2
P. 337 - août 2011 Retour au numéro
Article précédent
- Safety of investigative bronchoscopy in the Severe Asthma Research Program
- Wendy C. Moore, Michael D. Evans, Eugene R. Bleecker, William W. Busse, William J. Calhoun, Mario Castro, Kian Fan Chung, Serpil C. Erzurum, Douglas Curran-Everett, Raed A. Dweik, Benjamin Gaston, Mark Hew, Elliot Israel, Martin L. Mayse, Rodolfo M. Pascual, Stephen P. Peters, Lori Silveira, Sally E. Wenzel, Nizar N. Jarjour, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program ∗
- Life-course models of how the social environment affects childhood respiratory risk
- Edith Chen
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