Association between genital intraepithelial lesions and anal squamous intraepithelial lesions in HIV-negative women - 03/08/11
, Paulo C. Giraldo, PhD c, Antônio A. Horta, MD a, Rosana Grandelle, MD a, Ana K. Gonçalves, PhD d, Thaís Fonseca, MD b, José Eleutério, PhD e
Reprints: Cláudia Jacyntho, PhD, Rua Visconde de Pirajá, 550/2010, Ipanema–Rio de Janeiro/RJ–CEP, 22410-0002, BrazilRésumé |
Objective |
The objective of the study was to evaluate the risk of anal squamous intraepithelial lesions (ASILs) in immunocompetent women with genital squamous intraepithelial lesions (GSILs).
Study Design |
This was a cross-sectional study that included 260 immunocompetent women divided into 2 study groups: 1 group included 184 women diagnosed with GSIL by genital colposcopy and biopsy, and the other included 76 controls. All subjects were submitted to anoscopy followed by a biopsy if pertinent.
Results |
Of 184 GSIL women, 32 (17.4%) had ASIL (P < .001). The risk of ASIL was 13.1 times greater for GSIL women when there were 3 or 4 genital sites involved. All cases of high-grade ASIL were found in women with cervical GSILs. Among risk factors, anal intercourse without a condom demonstrated an important association with ASIL (prevalence ratio adjusted for age = 2.6).
Conclusion |
There seems to be a strong association between ASIL and multicentric GSIL. Another factor related to ASIL was the practice of unprotected anal intercourse.
Le texte complet de cet article est disponible en PDF.Key words : anal canal, anus neoplasms, cervical intraepithelial neoplasia, colposcopy
Plan
| Cite this article as: Jacyntho CMA, Giraldo PC, Horta AA, et al. Association between genital intraepithelial lesions and anal squamous intraepithelial lesions in HIV-negative women. Am J Obstet Gynecol 2011;205:115.e1-5. |
Vol 205 - N° 2
P. 115.e1-115.e5 - août 2011 Retour au numéro
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