Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children - 07/08/11
, Sheryl L. Rifas-Shiman, MPH c, Carlos A. Camargo, MD, DrPH a, d, Diane R. Gold, MD, MPH a, b, Matthew W. Gillman, MD, SM c, e, Augusto A. Litonjua, MD, MPH a, b
Reprint requests: Nancy E. Lange, MD, MPH, Channing Laboratory, Brigham and Women’s Hospital, 181 Longwood Ave, Boston, MA 02115.Abstract |
Background |
The rise in asthma prevalence over the last few decades may be a result of changes in prenatal or early-life environment, including maternal diet during pregnancy. Previous studies have found associations between individual foods or nutrients consumed during pregnancy and asthma or wheeze in children, but these may be confounded by overall dietary pattern.
Objective |
To determine whether overall maternal dietary pattern during pregnancy is associated with recurrent wheeze in children.
Methods |
A total of 1376 mother-infant pairs from Project Viva, a longitudinal prebirth cohort, who had responses for food frequency questionnaires in the first and second trimester and outcome data at 3 years of age were included. Multivariable logistic regression was used to look at associations between dietary pattern and the primary outcome of recurrent wheeze at 3 years. Overall dietary pattern was examined by using Mediterranean diet score, Alternate Healthy Eating Index modified for pregnancy (AHEI-P), and principal components analysis to look at Western and Prudent diets.
Results |
None of these dietary patterns was associated with the primary outcome of recurrent wheeze in children in either the crude or the multivariable model (multivariable model, odds ratio per 1-point increase in Mediterranean diet, 0.98 [95% CI, 0.89-1.08]; AHEI-P, 1.07 [0.87-1.30]; Prudent, 1.02 [0.83-1.26]; Western, 0.98 [0.81-1.19]).
Conclusion |
Overall dietary pattern during pregnancy is not associated with recurrent wheeze in this cohort. Maternal intake of individual nutrients may be more important determinants of offspring wheeze-associated illness than is dietary pattern.
Le texte complet de cet article est disponible en PDF.Key words : Asthma, dietary pattern, Mediterranean diet, healthy diet, principal components, childhood wheeze, pregnancy
Abbreviations used : AHEI-P, BMI, OR
Plan
| Supported by NIH HL61907, HL64925, HD34568, AI35786, HL68041, and HL007427. |
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| Disclosure of potential conflict of interest: C. A. Camargo Jr is a consultant and speaker for AstraZeneca; is on the advisory board for Dey; is a consultant, is a speaker, and is on the advisory board for GlaxoSmithKline; is a speaker of Merck; is a consultant and is on the advisory board for Novartis; and has received research support from the National Institutes of Health, AstraZeneca, Dey, GlaxoSmithKline, and Merck. D. R. Gold has received research support from the National Institutes of Health. The rest of the authors have declared that they have no conflict of interest. |
Vol 126 - N° 2
P. 250 - août 2010 Retour au numéro
Article précédent
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