Multiple Myeloma: Primary Bone Tumor with Systemic Manifestations - 07/08/11
Doi : 10.1016/j.nec.2007.09.001
Mark H. Bilsky, MD a, b, ⁎ 
, Syed Azeem, MD a
, Syed Azeem, MD a a Department of Neurosurgery, Box 71, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
b Department of Neurological Surgery at Weill Medical College of Cornell University and New York Presbyterian Hospital, 1300 York Avenue, Box 61, New York, NY 10021, USA
Corresponding author. Department of Neurosurgery, Box 71, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065.Abstract |
Multiple myeloma is a plasma cell dyscrasia that frequently involves the bone marrow of the spine. These tumors are typically chemosensitive and radiation sensitive. Multiple myeloma promotes osteoclast activation and osteoblast inhibition, resulting in osteolysis of the vertebral bodies and subsequent compression fractures. Rarely is open surgery for decompression and instrumentation indicated. The presence of diffuse osteoporosis in patients with multiple myeloma increases the probability of failed fixation in this population.
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© 2008
Elsevier Inc. Tous droits réservés.
Vol 19 - N° 1
P. 31-40 - janvier 2008 Retour au numéro
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