Segmental Brain Volumes and Cognitive and Perceptual Correlates in 15-Year-Old Adolescents with Low Birth Weight - 07/08/11

Doi : 10.1016/j.jpeds.2009.06.015

Marit Martinussen, MD, PhD ^a,^b,^⁎ , Dana W. Flanders, MD, DSc ^c, Bruce Fischl, PhD ^d,^e, Evelina Busa, MSc ^d, Gro C. Løhaugen, Cand Psychol ^a,^f, Jon Skranes, MD, PhD ^a,^f,^g, Torgil R. Vangberg, PhD ^h,ⁱ, Ann-Mari Brubakk, MD, PhD ^a,^g, Olav Haraldseth, MD, PhD ^h,^j, Anders M. Dale, PhD ^d,^e,^h,^k
^a Department of Laboratory Medicine, Children’s and Women’s Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
^b Department of Gynecology and Maternity Ward, St Olavs University Hospital, Trondheim, Norway
^c Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
^d Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA
^e MIT Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Boston, MA
^f Department of Pediatrics, Sorlandet Hospital, Arendal, Norway
^g Department of Pediatrics, St Olavs University Hospital, Trondheim, Norway
^h Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
ⁱ Department of Radiology Medical Faculty, University of Tromso, Tronso, Norway
^j Department of Medical Imaging, St Olavs University Hospital, Trondheim, Norway
^k Department of Neuroscience and Radiology, University of California, San Diego, CA

Reprint requests: Dr Marit Martinussen, Gynecology and Maternity Ward, St Olavs University Hospital, Olav Kyrres gt. 17, N-7006 Trondheim, Norway.

Abstract

Objective

To determine whether preterm very low birth weight (VLBW) or term born small for gestational age (SGA) adolescents have reduced regional brain volumes. We also asked which perinatal factors are related to reduced brain volume in VLBW adolescents, which regional brain volumes are associated with cognitive and perceptual functioning, and if these differ between the groups.

Study design

Fifty adolescent preterm VLBW (≤1500 g) births and 49 term SGA births (birth weight <10th percentile) were compared with 57 normal-weight term births. An automated MRI segmentation technique was used. Cognitive and perceptual functions were evaluated by WISC-III and Visual Motor Integration (VMI) tests.

Results

The VLBW group had reduced volumes for thalamus and cerebellar white matter (P < .002). The SGA group had smaller total brains, and proportionally smaller regional brain volumes. Cerebellar white matter in the VLBW, hippocampus in the SGA, and cerebral cortical in the control group were volumes that significantly predicted cognitive and perceptual functions.

Conclusions

We speculate that white matter injury may explain the impaired cognitive and perceptual functioning in the prematurely born, whereas hippocampal injury may be related to cognitive dysfunction in term SGA adolescents.

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Mots-clés : ICV, IQ, SGA, VLBW, VMI

Plan

Methods

Perinatal Factors in the VLBW Group

Funding information available at www.jpeds.com (Appendix). A.M.D. and B.F. are funded by CorTechs Labs, Inc. A.M.D. has equity in CorTechs Labs, Inc. The other authors declare no conflicts of interest.

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Vol 155 - N° 6

P. 848 - décembre 2009 Retour au numéro

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Segmental Brain Volumes and Cognitive and Perceptual Correlates in 15-Year-Old Adolescents with Low Birth Weight - 07/08/11

Abstract

Objective

Study design

Results

Conclusions

Plan

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