Polymorphisms in interleukin-1B and its receptor antagonist genes and the risk of chronic obstructive pulmonary disease in a Korean population: a case–control study - 08/08/11
Corresponding author. Department of Internal Medicine, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700-412, South Korea. Tel.: +82 53 420 5536; fax: +82 53 426 2046.Summary |
Background |
Although several studies have evaluated the association between interleukin-1B (IL1B) polymorphisms and the risk of chronic obstructive pulmonary disease (COPD), most of these studies have focused on −511C→T and −31T→C polymorphisms, and the results of these studies have been inconsistent. This study was conducted to investigate the association between four potentially functional polymorphisms of the IL1B gene (−3737C→T, −1464G→C, −511C→T, and −31T→C) and the risk of COPD. In addition, we examined a potential interaction of the IL1B polymorphisms with the VNTR polymorphism of the IL-1 receptor antagonist (IL1RN) gene in determining the risk of COPD.
Methods |
The IL1B and IL1RN genotypes were determined in 311 COPD patients and 386 healthy controls.
Results |
Individuals with at least one variant allele of the −511C→T and −31T→C polymorphisms were at a significantly increased risk for COPD when compared to carriers with each homozygous wild-type allele [adjusted odds ratio (OR) 1.53, 95% confidence interval (CI) 1.03–2.26, P=0.03; and adjusted OR 1.50, 95% CI 1.02–2.24, P=0.04, respectively]. When the COPD cases were stratified according to disease severity, the presence of at least one −511T and −31C alleles was significantly associated with severe COPD (adjusted OR 2.80, 95% CI 1.47–5.33, P=0.002; and adjusted OR 2.33, 95% CI 1.24–4.40, P=0.01, respectively), however, there was no significant association between the −511C→T and −31T→C genotypes and mild-to-moderate COPD. In addition, individuals carrying at least one IL1RN*2 allele were at a significantly lower risk for COPD compared to subjects carrying no IL1RN*2 allele (adjusted OR 0.51, 95% CI 0.26–0.98, P=0.04). In haplotype/diplotype analyses, individuals with one or two copies of the IL1B CCTC haplotype that carried the risk allele at all of the −3737C→T, −1464G→C, −511C→T, and −31T→C loci, were at a significantly increased risk of severe COPD when compared with subjects with zero copy of the CCTC haplotype (adjusted OR 1.96, 95% CI 1.16–3.29, P=0.01).
Conclusion |
These findings suggest that polymorphisms in the IL1B and IL1RN genes might be useful markers for determining genetic susceptibility to COPD in a Korean population.
Le texte complet de cet article est disponible en PDF.Keywords : IL1B, IL1RN, Polymorphisms, Chronic obstructive pulmonary disease
Plan
Vol 102 - N° 9
P. 1311-1320 - septembre 2008 Retour au numéro
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