Prognostic Implication of Hyperglycemia in Myocardial Infarction and Primary Angioplasty - 09/08/11
, Fiona M. Shrive, BSc, PhD a, b, 2, Todd J. Anderson, MD, FRCP(C) a, 3, Mouhieddin Traboulsi, MD, FRCP(C) a
Requests for reprints should be addressed to Matthew Worthley, MBBS, PhD, FRACP, Foothills Hospital, 1403-29th Street NW, Calgary, Alberta T2N-2T9 Canada.Abstract |
Purpose |
The study assessed the relationship of admission blood glucose level to in-hospital mortality in patients presenting with an ST-segment elevation myocardial infarction and treated with primary angioplasty.
Methods |
A total of 980 patients presenting with an ST-segment elevation myocardial infarction and treated exclusively with primary angioplasty were evaluated. Patients were divided into quartiles based on their admission blood glucose level: group 1 (≤6.6 mmol/L [≤119 mg/dL]), group 2 (6.7-7.8 mmol/L [120-140 mg/dL]), group 3 (7.9-10.0 mmol/L [141-180 mg/dL], and group 4 (≥10.1 mmol/L [≥181 mg/dL]. The primary end point was in-hospital mortality.
Results |
The mean age of the patient cohort was 62 years, 260 (27%) of whom were female. The mean admission blood glucose level was 9.1±4.4 mmol/L (164±79 mg/dL). At admission, 16% of this group were known to have diabetes. The in-hospital mortality rate was 3.8% (n=37), 5.2% in the diabetic group (n=8) and 3.5% (n=29) in the nondiabetic group. In-hospital mortality rates were significantly increased in patients with an elevated admission blood glucose level (P<.001). The in-hospital deaths in each admission blood glucose level quartile were 0.4% (n=1) in group 1, 2% (n=6) in group 2, 2% (n=6) in group 3, and 10% (n=24) in group 4.
Conclusions |
In this cohort of patients who were admitted with an ST-segment elevation myocardial infarction and treated exclusively with primary angioplasty, elevated admission blood glucose level is significantly associated with an increase in in-hospital mortality.
Le texte complet de cet article est disponible en PDF.Keywords : Glucose, Myocardial infarction, Primary angioplasty
Plan
Vol 120 - N° 7
P. 643.e1-643.e7 - juillet 2007 Retour au numéro
Article précédent
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- Javier D. Finkielman, Augustine S. Lee, Amber M. Hummel, Margaret A. Viss, Gregory L. Jacob, Henry A. Homburger, Tobias Peikert, Gary S. Hoffman, Peter A. Merkel, Robert Spiera, E. William St. Clair, John C. Davis, W. Joseph McCune, Andrea K. Tibbs, Steven R. Ytterberg, John H. Stone, Ulrich Specks, WGET Research Group (see Appendix)
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