Common and Specific Genetic Influences on Aggressive and Nonaggressive Conduct Disorder Domains - 09/08/11
, MICHAEL STALLINGS, Ph.D., SUSAN YOUNG, Ph.D., ROBIN CORLEY, Ph.D., SOO HYUN RHEE, Ph.D., HOPFER CHRISTIAN, M.D., JOHN HEWITT, Ph.D.ABSTRACT |
Objective |
To explore the genetic and environmental influences on DSM-IV conduct disorder (CD) aggressive and nonaggressive subscales, taking into account age and sex differences.
Method |
A community sample of 1,100 twin pairs (ages 11-18) was interviewed using the Diagnostic Interview Schedule for Children. Bivariate analyses, using variable threshold models accounting for age and sex differences, were used to determine the extent to which the genetic and environmental influences on aggressive and nonaggressive CD domains are shared or unique.
Results |
The phenotypic correlation between aggressive and nonaggressive CD domains was 0.32. The most parsimonious bivariate model included additive genetic effects and nonshared environmental effects only (AE model).
Conclusions |
The results of behavior genetic model fitting suggest that the DSM-IV CD domains are influenced by unique genetic and environmental factors, but also share some common genetic and environmental influences. A large percentage of the covariation (61%) is caused by genetic factors. These results are consistent with a previous report on the bivariate heritability of aggressive and nonaggressive antisocial behavior, but extend the findings to DSM-IV domains. J. Am. Acad. Child Adolesc. Psychiatry, 2006;45(5):570-577.
Le texte complet de cet article est disponible en PDF.Key Words : conduct disorder, twin study, aggressive, nonaggressive, heritability
Plan
| This research was supported by National Institute on Drug Abuse grants DA-11015, DA-12845, and DA-015522 , and grant HD10333 from the National Institute of Child Health and Human Development . Disclosure: The authors have no financial relationships to disclose. |
Vol 45 - N° 5
P. 570-577 - mai 2006 Retour au numéro
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