Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunity - 10/08/11
, Karen B. Fowler, DrPH, Guha Ashrith, MD, Sergio Stagno, MD, William J. Britt, MD, Robert F. Pass, MD, Suresh B. Boppana, MD
Reprint requests: Shannon A. Ross, MD, The University of Alabama at Birmingham, CHB 304, 1600 7th Ave S, Birmingham, AL 35233.Résumé |
Objective |
To define hearing outcomes in children with congenital cytomegalovirus (CMV) infection born to mothers with non-primary CMV infection.
Study design |
A cohort of 300 children with congenital CMV infection identified by newborn virologic screening at the University of Alabama Hospital and a private community hospital in which the type of maternal infection could be classified constituted the study population. Maternal infections were categorized by analyzing serum samples. Children were followed prospectively and underwent serial audiologic evaluations.
Results |
The frequency of hearing loss was not different between children born to mothers with non-primary infection (10%) and those with primary infection (11%). Significantly more children in the primary infection group had progressive and severe/profound hearing loss compared with children in the non-primary group. The frequency of bilateral, delayed onset, high-frequency, and fluctuating hearing loss was not different between the 2 groups. The mean age of diagnosis of hearing loss was 39 ± 53 months for children born to mothers with non-primary infection and 13 ± 21 months for the primary infection group (P = .16).
Conclusions |
Maternal preexisting seroimmunity to CMV does not provide complete protection against hearing loss in infants with congenital CMV infection.
Le texte complet de cet article est disponible en PDF.Mots-clés : CMV, dB, IgG, IgM, SNHL
Plan
| Supported in part by grants from the National Institutes of Health, the National Institute of Child Health and Human Development (P01 HD 10699), the National Institute of Allergy and Infectious Diseases (P01 AI43681, T32 AI052069), The National Institute on Deafness and Other Communication Disorders (R01 DC02139) and the General Clinical Research Center (M01 R00032). |
Vol 148 - N° 3
P. 332-336 - mars 2006 Retour au numéro
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