Longitudinal Changes in Insulin Sensitivity, Insulin Secretion, and β-Cell Function During Puberty - 10/08/11
See editorial, p 3, and related article, p 23.
Abstract |
Objective |
To determine longitudinal changes in insulin sensitivity (SI), insulin secretion, and β-cell function during puberty in white and black youth.
Study design |
The tolbutamide-modified frequently sampled intravenous glucose tolerance test and minimal modeling were used to measure SI, the acute insulin response to glucose (AIRg), and β-cell function (disposition index, DI) in white (n = 46) and black (n = 46) children (mean [±SD] age at baseline = 10.2 ± 1.7 years). Growth curve models (including 272 observations) with SI, AIRg, and DI regressed on Tanner stage were run after adjusting for covariates.
Results |
After adjusting for covariates, growth curve models revealed that SI decreased and subsequently recovered by the end of puberty in whites and blacks (both p < .05), AIRg decreased linearly across Tanner stages in both races (both p < .001), and DI decreased across puberty in blacks (p = .001) but not in whites (p = .2).
Conclusions |
White and black youth exhibited transient insulin resistance and diminished AIRg during puberty. The progressive decline in DI among blacks versus whites may reflect a unique effect of puberty on β-cell compensation in blacks. Future studies are needed to identify whether this difference contributes to the increased risk of type II diabetes in young blacks.
Le texte complet de cet article est disponible en PDF.Mots-clés : AIRg, BMI, CV, DI, GCRC, SI
Plan
| Supported by grants RO1HD33064 (to MIG), MO1RR00032 (to the General Clinical Research Center, Birmingham, Alabama) and P30DK56336 (to the Clinical Nutrition Research Unit, Birmingham, Alabama). GDCB was supported by a Canadian Institutes for Health Research Post-Doctoral Fellowship and the American Diabetes Association Mentor-Based Postdoctoral Fellowship Grant (awarded to MIG). |
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| Reprint requests: Reprints not available. |
Vol 148 - N° 1
P. 16-22 - janvier 2006 Retour au numéro
Article précédent
- Office-based Objective Measures in Childhood Asthma
- Joseph D. Spahn, Bradley E. Chipps
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- Robert H. Lustig, Michele L. Mietus-Snyder, Peter Bacchetti, Ann A. Lazar, Pedro A. Velasquez-Mieyer, Michael L. Christensen
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