Asthma mortality, inhaled steroids, and changing asthma therapy in Argentina (1990–1999) - 12/08/11
, Giorgio Walter Canonica c, Daniel Rocco d
Corresponding author at: Padiglione Maragliano, L. go R. Benzi 10, 16132 Genoa, Italy. Tel.: +39103538908; fax: +39103538904.Summary |
Background |
The asthma managing strategy has evolved and inhaled corticosteroids (ICS) are now the cornerstone of asthma treatment. Their effect on symptoms and exacerbations are well ascertained, whereas their effects on asthma mortality are still matter of debate. This ecological study evaluated asthma mortality rates and drug sales in the decade 1990–1999 in Argentina.
Methods |
Mortality (overall and adjusted for 5–34 years) was obtained from the Argentinean Epidemiological Institute, and data on the sales of antiasthma drugs were provided by the International Marketing Survey.
Results |
There was a significant change in drug sales in the spanned period: ICS +479%, inhaled β2 agonists +32%, theophylline −63%. The crude and adjusted mortality rates were 3.38 and 0.72 in the 1980–1989 decade, and 2.58 (
) and 0.38 (
) in the subsequent one. There was inverse correlation between inhaled corticosteroid sale and age-adjusted (5–34) asthma mortality (
; 
), and the same with global mortality rates (
; 
). A positive correlation was also seen between theophylline sales and mortality.
Conclusion |
The increased sale of ICS and possibly the decrease of theophylline use seem to be the more relevant factors associated with decreased asthma mortality in Argentina.
Le texte complet de cet article est disponible en PDF.Keywords : Asthma mortality, Inhaled corticosteroids, Gina guidelines, Theophylline, Ecological study
Plan
Vol 100 - N° 8
P. 1431-1435 - août 2006 Retour au numéro
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