Ocular Mast Cells and Mediators - 12/08/11
Doi : 10.1016/j.iac.2007.12.006
Anne-Marie A. Irani, MD ⁎ 
Division of Pediatric Allergy, Immunology, and Rheumatology, Virginia Commonwealth University Health System, 1112 East Clay Street, Mc Guire Hall Annex Room 4-421, Richmond, VA 23229, USA
Virginia Commonwealth University, Box 980225, Richmond, VA 23298-0225, USA.Abstract |
Mast cells have long been recognized for their role in immediate hypersensitivity reactions, by virtue of the presence of high affinity receptors for IgE (Fc
RI) on their surface. More recently, mast cells have been postulated to be involved in a variety of chronic inflammatory disorders as numerous mediators released by activated mast cells are characterized. This article summarizes current information on mast cell mediators, heterogeneity, and differentiation, and it reviews studies of mast cells in the normal eye and various ocular disorders.
Plan
| Portions of this article previously appeared in Irani A. Ocular mast cells and mediators. Immunol Allergy Clin North Am 1997;17(1):1–18. |
© 2008
Elsevier Inc. Tous droits réservés.
Vol 28 - N° 1
P. 25-42 - février 2008 Retour au numéro
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