Effect of Fish Oil Supplementation on Fatty Acid Status, Coordination, and Fine Motor Skills in Children with Phenylketonuria - 12/08/11
, 2, Hannes Reinhardt, BSc, Hans Demmelmair, PhD, Ania C. Muntau, MD, Berthold Koletzko, MD 1, ⁎ 
Reprint requests: Dr Berthold Koletzko, Professor of Paediatrics, Div. Metabolic Diseases and Nutritional Medicine, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, D-80337 Muenchen, Germany.Résumé |
Objective |
To investigate effects of long-chain omega-3 polyunsaturated fatty acids (LC-PUFA) on motor skills in patients with phenylketonuria (PKU).
Study design |
Thirty-six patients with PKU (1-11 years of age, good metabolic control: plasma phenylalanine ≤360 μmol/L for ≥6 months). We determined plasma phospholipid fatty acids, and in patients >4 years of age (N = 24) the motometric Rostock-Oseretzky Scale (ROS), before and after supplementation with fish oil for 3 months (15 mg docosahexaenoic acid [DHA]/kg body weight daily). ROS was also assessd in 22 age-matched controls.
Results |
Patients had low n-3 LC-PUFA in plasma phospholipids (DHA, 2.37 ± 0.10%; eicosapentaenoic acid [EPA], 0.4 ± 0.03%) and poorer ROS performance than controls (motor development index [MQ] 107 ± 3 vs 117 ± 3, P = .010). Supplementation increased phospholipid n-3 LC-PUFA (DHA 7.05 ± 0.24%; EPA 3.31 ± 0.19%; P < .001), decreased n-6 LC-PUFA (arachidonic acid, 9.26 ± 0.23% vs 6.76 ± 0.16%; P < .001) and improved ROS (MQ 115 ± 3.54, P = .011, paired t test). ROS was unchanged in 11 retested controls (MQ 115 ± 5.16, P = NS, paired t test multivariate analysis of variance [MANOVA] for time by group, P = .027). Patients tolerated fish oil well. Plasma phenylalanine remained unchanged.
Conclusion |
In patients with PKU, fish oil supplementation enhances n-3 LC-PUFA levels and improves motor skills.
Le texte complet de cet article est disponible en PDF.Abbreviations : ANOVA, DHA, EPA, LC-PUFA, MANOVA, MQ, PKU, ROS
Plan
| Supported in part by Scientific Hospital Supplies, Heilbronn, Germany, and the Child Health Foundation, Munich, Germany. Fish oil capsules were provided by Omega-Pharma, Berlin, Germany. |
Vol 150 - N° 5
P. 479-484 - mai 2007 Retour au numéro
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