Truncal Distribution of Fat Mass, Metabolic Profile and Hypothalamic-Pituitary Adrenal Axis Activity in Prepubertal Obese Children - 12/08/11
⁎ 
, Michelle Gayard-Cros, MD ¶, Ruth Andrew, PhD 
, Jean-Benoît Corcuff, MD, PhD †, Béatrice Jouret, MD ¶, Nicole Barthe, MD †, Paul Perez, MD, PhD ‡, Christine Germain, MSc ‡, Maïthé Tauber, MD, PhD ¶, Brian R. Walker, MD , Pierre Mormede, PhD §, Martine Duclos, MD, PhD § From the Department of Pediatric Endocrinology, Centre Hospitalier Universitaire de Bordeaux, France Endocrinology Unit, Centre of Cardiovascular Science, University of Edinburgh, United Kingdom. Reprint requests: Dr Pascal Barat, Pediatric Endocrinology, Centre Hospitalier Universitaire de Bordeaux, Hôpital des Enfants—Pellegrin, Place Amélie Raba Léon, 33076 Bordeaux Cedex, France.Résumé |
Objective |
To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children.
Study design |
TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity and reactivity have been studied in 45 prepubertal obese children aged 6 to 11 years (girls) and 6 to 13 years (boys).
Results |
After adjustment for whole body fat mass (%) (WBFM), TDFM correlated positively with insulin (r = 0.50, 95% CI [0.23; 0.70]) and homeostasis model assessment of insulin resistance (r = 0.52, 95% CI [0.25; 0.71]). When adjusted for WBFM, TDFM correlated positively with morning plasma cortisol (r = 0.38, 95% CI [0.15; 0.64]) in the total population. TDFM correlated negatively with the rise of salivary cortisol after a standard meal (r = −0.43, 95% CI [−0.71; −0.02]), obviously in girls. When adjusted for WBFM and TDFM, morning plasma cortisol correlated positively with total cholesterol (r = 0.41, 95% CI [0.11; 0.65]) and triglyceride (r = 0.44, 95% CI [0.14; 0.67]). The rise of salivary cortisol after a standard meal was negatively (r = −0.56, 95% CI [−0.85; −0.01]) and positively (r = 0.74, 95% CI [0.16; 0.94]) correlated with homeostasis model assessment of insulin resistance in boys and girls, respectively.
Conclusions |
Association exists in prepubertal obese children between TDFM and markers of HPA axis activity. These data suggest that HPA axis could be involved early in life in obesity associated with pejorative metabolic profile.
Le texte complet de cet article est disponible en PDF.Abbreviations : ACTH, BMI, CBG, DEXA, DXM, HOMA, HPA, QUICKI, TDFM, THE, THF, WBFM
Plan
| Supported by the Institut National de la Santé et de la Recherche Médicale. This work was funded by the Centre Hospitalier Universitaire de Bordeaux. |
Vol 150 - N° 5
P. 535 - mai 2007 Retour au numéro
Article précédent
- Mitochondrial DNA Depletion is a Prevalent Cause of Multiple Respiratory Chain Deficiency in Childhood
- Emmanuelle Sarzi, Alice Bourdon, Dominique Chrétien, Mohamed Zarhrate, Johanna Corcos, Abdelhamid Slama, Valérie Cormier-Daire, Pascale de Lonlay, Arnold Munnich, Agnès Rötig
- Adenotonsillectomy Improves Sleep, Breathing, and Quality of Life But Not Behavior
- Evelyn Constantin, Andrea Kermack, Gillian M. Nixon, Lee Tidmarsh, Francine M. Ducharme, Robert T. Brouillette
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?