Size at Birth, Infant Growth, and Blood Pressure at Three Years of Age - 12/08/11
, Sheryl L. Rifas-Shiman, MPH a, Janet Rich-Edwards, ScD c, d, Ken P. Kleinman, ScD a, Matthew W. Gillman, MD, SM a, e
Reprint requests: Mandy B. Belfort, MD, MPH, Division of Newborn Medicine, Hunnewell 437, Children’s Hospital Boston, 300 Longwood Ave, Boston, MA 02115.Résumé |
Objectives |
Our aim was to determine the extent to which infant growth—in weight-for-length—from birth to 6 months is associated with systolic blood pressure (SBP) at 3 years and to determine whether this association varies with birth size.
Study design |
In 530 children from the prospective cohort Project Viva, we measured birth length and 6-month weight and length with research standard instruments and SBP at age 3 years with a Dinamap automated recorder. We derived weight-for-length z-scores (WFL-z) and analyzed data with mixed effects regression models.
Results |
The mean (SD) WFL-z was 0.47 (0.75) at birth and 0.70 (0.96) at 6 months. Mean (SD) SBP at 3 years was 91.7 (9.4) mm Hg. After adjusting for confounding variables and birth WFL-z, child SBP was 1.0 mm Hg (95% CI 0.2, 1.8) higher for each z-score increment in 6-month WFL-z. The SBP of children in the lowest birth WFL-z quartile and the highest 6-month WFL-z quartile was 5.5 mm Hg (95% CI 2.6, 8.4) higher than that of children in the highest birth and lowest 6-month WFL-z quartiles.
Conclusions |
More rapid increase in weight-for-length, a measure of adiposity, in the first 6 months of life is associated with higher early childhood SBP, particularly in children who are thin at birth.
Le texte complet de cet article est disponible en PDF.Abbreviations : BMI, CI, SBP, WFL-z
Plan
| Supported by NIH (HD 34568, HL 64925, HL 68041), Harvard Medical School, Harvard Pilgrim Health Care Foundation, and Harvard Pediatric Health Services Research Fellowship Program (HRSA T32 HP10018). |
Vol 151 - N° 6
P. 670-674 - décembre 2007 Retour au numéro
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