Tea consumption and basal cell and squamous cell skin cancer: Results of a case-control study - 12/08/11
, Therese A. Stukel, PhD f, Ann E. Perry, MD b, Michael S. Zens, PhD a, Steven K. Spencer, MD c, Margaret R. Karagas, PhD a, d, e
Reprint requests: Judy R. Rees, BM, BCh, PhD, One Medical Center Dr, 7927 Rubin Bldg, Lebanon, NH 03756.Lebanon and Hanover, New Hampshire, and Toronto, Ontario, Canada
Abstract |
Background |
Tea constituents, including polyphenols, are hypothesized to have chemopreventive properties, and inhibit the induction of skin cancers in animal models.
Objective |
To explore the association between regular tea consumption (≥1 cup/d for ≥1 month) and the incidence of squamous cell (SCC) and basal cell (BCC) carcinomas.
Methods |
A population-based case-control study of 770 individuals with BCC, 696 with SCC, and 715 age- and sex-matched control subjects.
Results |
After adjustment for age, sex, and lifetime history of painful sunburns, ever having consumed tea regularly was associated with a significantly lower risk of SCC (odds ratio [OR] = 0.70; 95% confidence interval [CI] 0.53-0.92), especially among long-term drinkers (≥47 years consumption: SCC, OR = 0.49; 95% CI 0.29-0.83; P for trend = .008) and among those consuming ≥2 cups/d (OR = 0.65; 95% CI 0.44-0.96; P for trend = 0.013). After adjustment for age and sex, ever having consumed tea regularly was weakly associated with BCC risk (OR = 0.79; 95% CI 0.63-0.98).
Limitations |
Our case-control study was susceptible to recall bias and to confounding by unknown cancer risk factors associated with tea consumption.
Conclusions |
Our findings support the existence of an inverse association between tea consumption and skin carcinogenesis.
Le texte complet de cet article est disponible en PDF.Abbreviations used : BCC, CI, NMSC, OR, SCC
Plan
| Supported by grant CA57494 from the National Institute of Health, National Cancer Institute. Conflicts of interest: None declared. |
Vol 56 - N° 5
P. 781-785 - mai 2007 Retour au numéro
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