Fatty Acid Ethyl Esters: Quantitative Biomarkers for Maternal Alcohol Consumption - 15/08/11
, Luis Manuel Santiago, MPH, Mary Ann O'Riordan, MS, Kevin Buck, BA, Siemay C. Lee, MD, Lynn T. Singer, PhD
Reprint requests: Cynthia F. Bearer, MD, PhD, Department of Pediatrics, Rainbow Babies & Children's Hospital, 11100 Euclid Ave, Suite 3100, Cleveland, OH 44106-6010.Abstract |
Objective |
To develop a laboratory marker to identify newborns exposed to alcohol.
Study design |
Meconium was collected from 30 infants from Jordan who were unexposed and from 248 Cleveland study infants of varying exposure status. Retrospective maternal alcohol histories were obtained. Fatty acid ethyl esters (FAEEs) were quantified with gas chromatography/flame ionization and compared between abstainers and non-abstainers to identify FAEEs of interest. The area under the receiver operating characteristic curve, sensitivity, specificity, and positive and negative predictive values were calculated by using definitions of drinking obtained from a graphical representation.
Results |
Six of 7 FAEEs were significantly different between the non-abstainers and at least 1 of 2 of the abstaining groups. FAEEs best predicted drinks per drinking day, and ethyl linoleate had the greatest area under the curve (76%), with a sensitivity rate of 88%, a specificity rate of 64%, a positive predictive value of 9%, and a negative predictive value of 99%. No combination of FAEEs was better than a single ester for identifying drinkers.
Conclusion |
Ethyl linoleate in meconium is a useful biological marker for identifying infants not exposed in utero to high levels of alcohol in a high-risk, substance-abusing, clinic-based sample.
Le texte complet de cet article est disponible en PDF.Mots-clés : AUC, DRDD, DRWK, DYWK, FAS, FAEE, GC/FID, GC/MS, NPV, PPV, ROC
Plan
| Cynthia F. Bearer, MD, PhD, currently holds a patent for the measurement of fatty acid ethyl ester in meconium. Currently, there are no business relationships based on this patent. Supported by grants from the National Institute on Environmental Health Science/National Institutes of Health/Environmental Protection Agency (P01 ES11261), Association of American Medical Colleges/Centers for Disease Control and Prevention/Agency for Toxic Substance and Disease Registry Cooperative Agreement (MM-0122-02/02), Association of Retarded Citizens of the United States (C.F.B.), and National Institute on Drug Abuse (R01-07259; L.T.S.). |
Vol 146 - N° 6
P. 824-830 - juin 2005 Retour au numéro
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