Exposure to traffic: Lung function and health status in adults with asthma - 15/08/11
, Gillian Earnest, MS a, Patricia P. Katz, PhD a, b, Edward H. Yelin, PhD a, b, Mark D. Eisner, MD, MPH a, Hubert Chen, MD a, Laura Trupin, MPH a, b, Fred Lurmann, MS e, Paul D. Blanc, MD a, c
Reprint requests: John R. Balmes, MD, University of California—San Francisco, Box 0843, San Francisco, CA 94143-0843.Abstract |
Background |
Exposure to traffic has been associated with asthma outcomes in children, but its effect on asthma in adults has not been well studied.
Objective |
To test the hypothesis that lung function and health status are associated with traffic exposures.
Methods |
We measured FEV1 % predicted, general health status using the Physical Component Scale of the 12-item Short Form (SF-12 PCS), and quality of life (QoL) using the Marks Asthma Quality of Life questionnaire in a cohort of adults with asthma or rhinitis (n = 176; 145 with asthma). We assessed exposures to traffic by geocoding subjects’ residential addresses and assigning distance to roadways. Associations between distance to nearest roadway and distance to nearest major roadway and FEV1 % predicted or SF-12 PCS were studied by using linear regression.
Results |
FEV1 % predicted was positively associated with distance from both nearest roadway (P = .01) and nearest major roadway (P = .02). SF-12 PCS and QoL were not significantly associated with either traffic variable. Adjustment for income, smoking, and obesity did not substantively change the associations of the traffic variables with FEV1 % predicted (P = .04 for nearest roadway and P = .02 for nearest major roadway) and did not cause associations with either SF-12 PCS or QoL to become significant.
Conclusions |
Traffic exposure was associated with decreased lung function in adults with asthma.
Le texte complet de cet article est disponible en PDF.Key words : Asthma, traffic, lung function, health status
Abbreviations used : Asthma QoL, BMI, GIS, QoL, SES, SF-12 PCS
Plan
| Supported by grant #R01 ES 10906 to P.D.B. from the National Institute of Environmental Health Sciences. |
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| Disclosure of potential conflict of interest: J. R. Balmes receives grant support from the National Institutes of Health, the Flight Attendants Medical Research Institute (FAMRI), the California Air Resource Board, and the Centers for Disease Control and Prevention and has provided legal consultation on air pollution health effects for the California Department of Justice. G. Earnest has received grant support from the National Institutes of Health. P. P. Katz has received grant support from the National Institutes of Health. E. H. Yelin has received grant support from the National Institutes of Health. M. D. Eisner has received grant support from the National Heart, Lung, and Blood Institute/National Institutes of Health, the FAMRI, the National Institute of Environmental Health Sciences/National Institutes of Health, and Genentech and has provided legal consultation/expert witness testimony in cases related to pulmonary hypertension and reactive airways dysfunction syndrome. F. Lurmann has received grant support from the University of California—Berkeley, the University of California—San Francisco, California State University—Fullerton, and the University of Southern California. P. D. Blanc receives grant support from the National Institutes of Health and FAMRI and has provided legal consultation/expert witness testimony in cases related to waterproofing inhalation injury. The rest of the authors have declared that they have no conflict of interest. |
Vol 123 - N° 3
P. 626-631 - mars 2009 Retour au numéro
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