Breakdown in epithelial barrier function in patients with asthma: Identification of novel therapeutic approaches - 15/08/11
Reprint requests: Donna E. Davies, PhD, Mailpoint 810, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom.Abstract |
The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment. These barriers serve to maintain normal homeostasis, but when compromised, the immunologic barrier becomes activated to protect the internal milieu of the lung. We discuss what is currently understood about abnormalities in these barrier functions in patients with asthma and consider novel therapeutic opportunities that target this key structure.
Le texte complet de cet article est disponible en PDF.Key words : Asthma, epithelium, tight junction, innate immunity, permeability, allergen, virus
Abbreviations used : BEC, DC, EGF, IP-10, MC, TJ, TLR, ZO
Plan
| (Supported by an educational grant from Merck & Co., Inc.) |
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| Series editors: Joshua A. Boyce, MD, Fred Finkelman, MD, William T. Shearer, MD, PhD, and Donata Vercelli, MD |
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| Terms in boldface and italics are defined in the glossary on page 24. |
Vol 124 - N° 1
P. 23-34 - juillet 2009 Retour au numéro
Article précédent
- Intestinal barrier function: Molecular regulation and disease pathogenesis
- Breakdown in epithelial barrier function in patients with asthma: Identification of novel therapeutic approaches
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