Combined Esterified Estrogen and Methyltestosterone Treatment for Dry Eye Syndrome in Postmenopausal Women - 18/08/11
, Daniel Wasilewski, MD a, Jonathan Song, MD a, b, Ronald E. Smith, MD a, b
Inquiries to Samuel C. Yiu, MD, PhD, 1450 San Pablo Street DEI5704, Los Angeles, CA 90033; fax: (323) 442-6515;Résumé |
Purpose |
To determine whether systemic replacement with combined esterified estrogen (EE) and methyltestosterone (MT) (EE + MT) would reduce symptoms and promote clinical improvement in postmenopausal women with dry eye syndrome (DES).
Design |
Retrospective, noncomparative, interventional case series.
Methods |
Investigators reviewed the charts of 11 postmenopausal women treated within the last 3 years with EE + MT.
Results |
The mean patient age was 65.2 years (standard deviation [SD] 11.4, range 48–84 years). The mean treatment duration was 12.2 months (SD 6.2 months, range 4–24 months). Ten (91%) of 11 patients reported improvement in dry eye symptoms while receiving treatment. For these 10, relief occurred after an average of 4.1 months of treatment (SD 3.2, range, 1–9 months).
Conclusions |
Treatment with EE + MT may be efficacious for DES of various etiologies. A randomized placebo-controlled trial is planned to further evaluate these encouraging findings.
Le texte complet de cet article est disponible en PDF.| Supported by an unrestricted grant from Research to Prevent Blindness, New York, New York, NEI grant EYO3040, and by a Baxter Foundation Junior Faculty Award to Dr. Yiu. |
Vol 139 - N° 6
P. 1109-1110 - juin 2005 Retour au numéro
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