Linezolid-induced Optic Neuropathy - 18/08/11
, Keiko Hayashi, MD a, Hideyuki Yamada, MD a, Masato Wakakura, MD b
Inquiries to Tomohiro Saijo, MD, Department of Ophthalmology, Kawakita General Hospital, 1-7-3 Asagayakita, Suginami, Tokyo 166-8658, Japan; fax: (+81)3-3338-2986;Résumé |
Purpose |
To report a case of optic neuropathy associated with prolonged use of a new antibiotic, linezolid.
Design |
Interventional case report.
Methods |
Optic and peripheral neuropathy occurred in a 27-year-old woman who was undergoing prolonged linezolid therapy for osteomyelitis. The use of corticosteroid exacerbated visual loss. Discontinuation of the linezolid therapy resulted in marked improvement of optic neuropathy.
Results |
Linezolid-induced optic neuropathy was diagnosed in this case, because prolonged linezolid therapy was performed at a higher dose than usual and because the patient recovered after linezolid therapy was discontinued.
Conclusions |
With prolonged linezolid therapy, ophthalmologists should be aware that bilateral optic neuropathy can occur and that corticosteroids are not indicated for this neuropathy.
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Vol 139 - N° 6
P. 1114-1116 - juin 2005 Retour au numéro
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