Association between maternal serum cytokine profiles at 7-10 weeks' gestation and birthweight in small for gestational age infants - 19/08/11
Résumé |
Objective |
The purpose of this study was to investigate whether birth of a small-for-gestational-age (SGA) baby (birthweight, <10th percentile) is preceded by altered maternal serum cytokine profiles at early pregnancy, compared with control babies (birthweight, 30-80th percentile).
Study Design |
A retrospective case-control study of maternal serum collected prospectively across 7-10 weeks of gestation from women attending their first prenatal visit (SGA, 57 cases; control subjects, 71 cases selected retrospectively). Serum concentrations of 27 cytokines were measured in each sample and analyzed by 2-way analysis of variance and nonparametric tests. Logistic regression was used for predictive modeling.
Results |
Of 21 detectable cytokines/chemokines, 14 analytes varied significantly (P ≤ .030) among those women who were destined to deliver an SGA baby, when compared with control subjects. Of the cytokines that varied in association with SGA, interferon-γ concentrations increased, and major proinflammatory (interleukin [IL]-2, -7, -12) and antiinflammatory (IL-1 receptor antagonist, -4, -10, -13) cytokine concentrations decreased. Eotaxin and macrophage inflammatory protein-1⍺ were higher; monocyte chemoattractant protein-1 and IL-8 were lower.
Conclusion |
SGA births may be preceded by altered immune cytokine profiles at 7-10 weeks of gestation.
Le texte complet de cet article est disponible en PDF.Key words : cytokine profile, disease prediction, inflammatory, immune system, small-for-gestational-age
Plan
| Supported by the Medical Research Foundation for Women and Babies and The National Health and Medical Research Council of Australia, Grant nos. 509127 (H.M.G., S.T.), 490970 (S.T.), and 454880 (Y.J.H.). |
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| Reprints not available from the authors. |
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| Cite this article as: Georgiou HM, Thio YS, Russell C, et al. Association between maternal serum cytokine profiles at 7-10 weeks' gestation and birthweight in small for gestational age infants. Am J Obstet Gynecol 2011;204:415.e1-12. |
Vol 204 - N° 5
P. 415.e1-415.e12 - mai 2011 Retour au numéro
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