Choriodecidua and amnion exhibit selective leukocyte chemotaxis during term human labor - 19/08/11
Résumé |
Objective |
The purpose of this study was to compare the chemotactic activity of the choriodecidua and amnion, and to identify the phenotype of the leukocytes chemoattracted by each tissue.
Study Design |
Amnion, choriodecidua and whole fetal membranes extracts were obtained from women at term (>37 weeks of gestation) with or without labor (n = 5 each). Extracts were assayed for leukocyte chemotactic activity, and the number and phenotype of the chemoattracted leukocytes were characterized by flow cytometry.
Results |
Although all of the extracts exhibited chemotactic activity, more leukocytes were chemoattracted by the choriodecidua and the whole fetal membranes during labor compared with no labor (P = .010, .008). During labor the choriodecidua is responsible for granulocyte, T-lymphocyte, monocyte, and natural killer-cell chemoattraction, and the amnion is responsible for B-lymphocyte chemoattraction.
Conclusion |
Choriodecidua and amnion exhibit chemotactic activity for selective leukocytes and thus, each fetal membrane differentially regulates leukocyte chemotactic activity during labor.
Le texte complet de cet article est disponible en PDF.Key words : amnion, chemotaxis, choriodecidua, fetal membranes, labor, leukocytes
Plan
| Supported by the Alberta Innovates-Health Solutions Interdisciplinary Preterm Birth and Healthy Outcomes Team (PreHOT). F.V.O. was supported by CONACyT-SALUD7036 and 69353. |
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| Reprints not available from the authors. |
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| Cite this article as: Gomez-Lopez N, Vadillo-Perez L, Nessim S, et al. Choriodecidua and amnion exhibit selective leukocyte chemotaxis during term human labor. Am J Obstet Gynecol 2011;204:364.e9-16. |
Vol 204 - N° 4
P. 364.e9-364.e16 - avril 2011 Retour au numéro
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